Fragmented QRS complex is a diagnostic tool in patients with left ventricular diastolic dysfunction

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• 作者：Yoshiro Onoue ; Yasuhiro Izumiya ; Shinsuke Hanatani ; Yuichi Kimura…
• 关键词：Fragmented QRS ; Left ventricular diastolic dysfunction ; Fibrosis ; Hypertrophy
• 刊名：Heart and Vessels
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：31
• 期：4
• 页码：563-567
• 全文大小：438 KB
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• 作者单位：Yoshiro Onoue (1)
  Yasuhiro Izumiya (1)
  Shinsuke Hanatani (1)
  Yuichi Kimura (1)
  Satoshi Araki (1)
  Kenji Sakamoto (1)
  Eiichiro Yamamoto (1)
  Kenichi Tsujita (1)
  Tomoko Tanaka (1)
  Megumi Yamamuro (1)
  Sunao Kojima (1)
  Koichi Kaikita (1)
  Seiji Hokimoto (1)
  Hisao Ogawa (1)
  
  1. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  Biomedical Engineering
  Interventional Radiology
  Ultrasound
  
• 出版者：Springer Japan
• ISSN：1615-2573

文摘

Fragmented QRS complex (fQRS) on 12-lead ECG is associated with myocardial fibrosis and ischemic scar. Interstitial fibrosis is one of the histological characteristics of left ventricular diastolic dysfunction (LVDD). However, the clinical importance of fQRS in patients with LVDD remains unclear. Here, we assessed the hypothesis that the presence of fQRS is associated with disease severity in patients with LVDD, and could be used as an additional parameter to differentiate patients with heart failure with preserved ejection fraction (HFpEF) from LVDD. We analyzed 12-lead ECG of 239 patients with LVDD. The patients were divided into two groups according to the presence or absence of fQRS; 88 patients had fQRS (fQRS group) and 151 patients did not have fQRS (non-fQRS group). The percentage of patients with heart failure in the fQRS group was significantly higher than that in the non-fQRS group. The levels of B-type natriuretic peptide (BNP) and high-sensitive troponin T were significantly higher in the fQRS group than those in the non-fQRS group. In univariate logistic regression analysis, fQRS was associated with the presence of heart failure in patients with LVDD. Multivariate logistic regression analysis identified fQRS and BNP as independent indicators for HFpEF. In conclusion, the presence of fQRS on the ECG could be used as an additional tool to differentiate HFpEF from LVDD.