Protective effects of appropriate Zn2+ levels against UVB radiation-induced damage in human lens epithelial cells in vitro

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• 作者：Yuxiang Du ; Dadong Guo ; Qiuxin Wu ; Jing Shi…
• 关键词：Ultraviolet B ; Calcium homeostasis ; Plasma membrane calcium ATPase ; Sarcoplasmic endoplasmic reticulum calcium ATPase ; Reactive oxygen species
• 刊名：Journal of Biological Inorganic Chemistry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：21
• 期：2
• 页码：213-226
• 全文大小：1,640 KB
• 参考文献：1.Roberts JE (2001) J Photoch Photobiol B 64:136–143CrossRef
  2.Ichihashi M, Ueda M, Budiyanto A, Bito T, Oka M, Fukunaga M, Tsuru K, Horikawa T (2003) Toxicology 189:21–39CrossRef PubMed
  3.Krutmann J (2000) J Dermatol Sci 23(Suppl 1):S22–S26CrossRef PubMed
  4.Paterson CA, Zeng J, Husseini Z, Borchman D, Delamere NA, Garland D, Jimenez-Asensio J (1997) Curr Eye Res 16:333–338CrossRef PubMed
  5.Carafoli E (2004) Trends Biochem Sci 29:371–379CrossRef PubMed
  6.Clark JI, Mengel L, Bagg A, Benedek GB (1980) Exp Eye Res 31:399–410CrossRef PubMed
  7.Hightower KR (1985) Curr Eye Res 4:453–459CrossRef PubMed
  8.Duncan G, Jacob TJ (1984) Ciba Found Symp 106:132–152PubMed
  9.Chiesa R, Sredy J, Spector A (1985) Curr Eye Res 4:897–903CrossRef PubMed
  10.Brini M (2009) Pflugers Arch 457:657–664CrossRef PubMed
  11.Marian MJ, Mukhopadhyay P, Borchman D, Tang D, Paterson CA (2007) Cell Calcium 41:87–95CrossRef PubMed
  12.de la Bastie D, Levitsky D, Rappaport L, Mercadier JJ, Marotte F, Wisnewsky C, Brovkovich V, Schwartz K, Lompré AM (1990) Circ Res 66:554–564CrossRef PubMed
  13.Anger M, Samuel J-L, Marotte F, Wuytack F, Rappaport L, Lompre′ A-M (1993) FEBS Lett 334:45–48CrossRef PubMed
  14.Ahuja RP, Borchman D, Dean WL, Paterson CA, Zeng J, Zhang Z, Ferguson-Yankey S, Yappert MC (1999) Free Radical Biol Med 27:177–185CrossRef
  15.Zhang YK, Zhu DF, Zhang YP, Chen HZ, Xiang J, Lin XQ (2015) Low pH-induced changes of antioxidant enzyme and ATPase activities in the roots of rice (Oryza sativa L.) seedings. PLoS One 10(2):e0116971CrossRef PubMed PubMedCentral
  16.Da Costa R, Botana D, Piñero S, Proverbio F, Marín R (2015) Cadmium inhibits motility, activities of plasma membrane Ca2+ -ATPase and axonemal dynein-ATPase of human spermatozoa. Andrologia. doi:10.​1111/​and.​12466
  17.Borchman D, Paterson C, Delamere N (1988) Selective inhibition of membrane ATPases by hydrogen peroxide in the lens of the eye. Basic Life Sci 49:1029–1033PubMed
  18.Chang RC, Shi L, Huang CC, Kim AJ, Ko ML, Zhou B, Ko GY (2015) High-fat diet-induced retinal dysfunction. Invest Ophthalmol Vis Sci 56(4):2367–2380CrossRef PubMed PubMedCentral
  19.Marian MJ, Mukhopadhyay P, Borchman D, Tang D, Paterson CA (2008) Open Ophthalmol J 2:123–129CrossRef PubMed PubMedCentral
  20.Yamaguchi M, Weitzmann MN (2011) Mol Cell Biochem 355:179–186CrossRef PubMed
  21.Seo HJ, Cho YE, Kim T, Shin HI, Kwun IS (2010) Nutr Res Pract 4:356–361CrossRef PubMed PubMedCentral
  22.Hogstrand C, Kille P, Nicholson RI, Taylor KM (2009) Trends Mol Med 15:101–111CrossRef PubMed
  23.Zhao L, Chen W, Taylor KM, Cai B, Li X (2007) Biochem Biophys Res Commun 363:82–88CrossRef PubMed
  24.Murakami M, Hirano T (2008) Cancer Sci 99:1515–1522CrossRef PubMed
  25.Dubi N, Gheber L, Fishman D, Sekler I, Hershfinkel M (2008) Carcinogenesis 29:1692–1700CrossRef PubMed
  26.Yamasaki S, Sakata-Sogawa K, Hasegawa A, Suzuki T, Kabu K, Sato E, Kurosaki T, Yamashita S, Tokunaga M, Nishida K, Hirano T (2007) J Cell Biol 177:637–645CrossRef PubMed PubMedCentral
  27.Chiang HM, Chen HC, Chiu HH, Chen CW, Wang SM, Wen KC (2013) Evid Based Compl Alt 2013:324864
  28.Lee CW, Ko HH, Lin CC, Chai CY, Chen WT, Yen FL (2013) Food Chem Toxicol 60C:123–129CrossRef
  29.Mantena SK, Katiyar SK (2006) Free Radic Biol Med 40:1603–1614CrossRef PubMed
  30.Richard MJ, Guiraud P, Leccia MT, Beani JC, Favier A (1993) Biol Trace Elem Res 37:187–199CrossRef PubMed
  31.Parat MO, Richard MJ, Pollet S, Hadjur C, Favier A, Béani JC (1997) J Photochem Photobiol B 37:101–106CrossRef PubMed
  32.Arends SJ, Damoiseaux JG, Duijvestijn AM, Debrus-Palmans L, Vroomen M, Boomars KA, Rocca HP, Reutelingsperger CP, Tervaert JW, van Paassen P (2013) Clin Exp Immunol 174:433–440CrossRef PubMed PubMedCentral
  33.Guo D, Wu C, Li J, Guo A, Li Q, Jiang H, Chen B, Wang X (2009) Nanoscale Res Lett 4:1395–1402CrossRef PubMed PubMedCentral
  34.Guo D, Bi H, Wang D, Wu Q (2013) Int J Biochem Cell Biol 45:1849–1859CrossRef PubMed
  35.Wu Q, Guo D, Bi H, Wang D, Du Y (2013) Mol Cell Biochem 382:263–272CrossRef PubMed
  36.Livak KJ, Schmittgen TD (2001) Methods 25:402–408CrossRef PubMed
  37.Yao J, Liu Y, Wang X, Shen Y, Yuan S, Wan Y, Jiang Q (2009) Int J Mol Med 24:153–159PubMed
  38.Yao K, Zhang L, Zhang Y, Ye P, Zhu N (2008) Mol Vis 14:1865–1871PubMed PubMedCentral
  39.McCord MC, Aizenman E (2013) P Natl Acad Sci USA 110:13988–13993CrossRef
  40.Wang CL, Liu C, Niu LL, Wang LR, Hou LH, Cao XH (2013) Cell Biochem Biophys 67:1433–1439CrossRef PubMed PubMedCentral
  41.Andley UP, Lewis RM, Reddan JR, Kochevar IE (1994) Invest Ophth Vis Sci 35:367–373
  42.Andley UP, Weber JG (1995) Photochem Photobiol 62:840–846CrossRef PubMed
  43.Andley UP, Malone JP, Townsend RR (2011) Invest Ophthalmol Vis Sci 52:8330–8341CrossRef PubMed PubMedCentral
  44.Saito T, Tezuka T, Konno R, Fujii N (2010) Jpn J Ophthalmol 54:486–493CrossRef PubMed
  45.Bozym RA, Chimienti F, Giblin LJ, Gross GW, Korichneva I, Li Y, Libert S, Maret W, Parviz M, Frederickson CJ, Thompson RB (2010) Exp Biol Med (Maywood) 235:741–750CrossRef
  46.Guo D, Du Y, Wu Q, Jiang W, Bi H (2014) Arch Biochem Biophys 159:425–433
  47.Canani RB, Cirillo P, Buccigrossi V, Ruotolo S, Passariello A, De Luca P, Porcaro F, De Marco G, Guarino A (2005) J Infect Dis 191:1072–1077CrossRef PubMed
  48.Moltedo O, Verde C, Capasso A, Parisi E, Remondelli P, Bonatti S, Alvarez-Hernandez X, Glass J, Alvino CG, Leone A (2000) J Biol Chem 275:31819–31825CrossRef PubMed
  49.Zödl B, Zeiner M, Sargazi M, Roberts NB, Marktl W, Steffan I, Ekmekcioglu C (2003) J Inorg Biochem 97:324–330CrossRef PubMed
  50.Cario E, Jung S, Harder D’Heureuse J, Schulte C, Sturm A, Wiedenmann B, Goebell H, Dignass AU (2000) Eur J Clin Invest 30:419–428CrossRef PubMed
  51.Nakatani T, Tawaramoto M, OpareKennedy D, Kojima A, Matsui-Yuasa I (2000) Chem Biol Interact 125:151–163CrossRef PubMed
  52.Lagouge M, Larsson NG (2013) J Intern Med 273:529–543CrossRef PubMed PubMedCentral
  53.Sharir H, Zinger A, Nevo A, Sekler I, Hershfinkel M (2010) J Biol Chem 285:26097–26106CrossRef PubMed PubMedCentral
  54.Berridge MJ (2009) Biochim Biophys Acta 1793:933–940CrossRef PubMed
  55.Penniston JT, Padányi R, Pászty K, Varga K, Hegedus L, Enyedi A (2014) J Cell Sci 127:72–84CrossRef PubMed
  56.Williams MR, Riach RA, Collison DJ, Duncan G (2001) Invest Ophthalmol Vis Sci 42:1009–1017PubMed
  57.Hadri L, Pavoine C, Lipskaia L, Yacoubi S, Lompré AM (2006) Biochem J 394:27–33CrossRef PubMed PubMedCentral
  58.Liu L, Paterson CA, Borchman D (2002) Exp Eye Res 75:583–590CrossRef PubMed
  59.Ermak G, Davies KJ (2002) Mol Immunol 38:713–721CrossRef PubMed
  60.Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR (2005) J Neurosci 25:9176–9184CrossRef PubMed
  61.Doughan AK, Harrison DG, Dikalov SI (2008) Circ Res 102:488–496CrossRef PubMed
  62.Bedard K, Krause KH (2007) Physiol Rev 87:245–313CrossRef PubMed
  
• 作者单位：Yuxiang Du (1)
  Dadong Guo (2)
  Qiuxin Wu (3)
  Jing Shi (4)
  Dongmei Liu (3)
  Hongsheng Bi (2) (3)
  
  1. Shandong University of Traditional Chinese Medicine, 250002, Jinan, China
  2. Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, 250002, Jinan, China
  3. Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, 250002, Jinan, China
  4. College of Chemical and Molecular Technology, Qingdao University of Science and Technology, 266035, Qingdao, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Microbiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1327

文摘

As one of the crucial factors of cataract formation, ultraviolet B (UVB) can lead to apoptosis of human lens epithelial cells. Zinc, a cell-protective metal against various toxic compounds, plays an important role in protecting target cells from damage. Nevertheless, it is still unclear whether zinc exhibits protective effect on human lens epithelial cells (HLE B-3) against UVB-induced damage. In this study, we investigated the protective effect of zinc chloride (ZnCl₂) on UVB-induced HLE B-3 cell damage, explored the molecular mechanisms using real-time cell electronic sensing system, flow cytometry, real-time quantitative PCR and enzyme-linked immunosorbent assay techniques. The results show that ZnCl₂ is a potential inhibitor of UVB-induced HLE B-3 cell damage, and the underlying mechanisms are involved in decreasing the overproduction of reactive oxygen species and mitochondrial dysfunction, promoting intracellular calcium homeostasis recovery, and thus maintaining cell normal physiological functions. Taken together, our findings suggest that appropriate zinc levels have potential for protecting HLE B-3 cells against UVB-induced damage, and this finding may be clinically useful.