Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model

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• 作者：Caroline Vandeputte (12)
  Cindy Casteels (12)
  Tom Struys (34)
  Michel Koole (12)
  Daisy van Veghel (25)
  Nele Evens (25)
  Anneleen Gerits (12)
  Tom Dresselaers (24)
  Ivo Lambrichts (3)
  Uwe Himmelreich (24)
  Guy Bormans (25)
  Koen Van Laere (126) koen.vanlaere@uzleuven.be
• 关键词：CB1 receptor &#8211 ; CB2 receptor &#8211 ; Positron emission tomography &#8211 ; Photothrombotic stroke &#8211 ; [18F]MK ; 9470 &#8211 ; [11C]NE40
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2012
• 出版时间：November 2012
• 年：2012
• 卷：39
• 期：11
• 页码：1796-1806
• 全文大小：996.8 KB
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• 作者单位：1. Division of Nuclear Medicine, KU Leuven, Leuven, Belgium2. Molecular Small Animal Imaging Center, MoSAIC, KU Leuven, Leuven, Belgium3. Laboratory of Histology, Biomedical Research Institute, Hasselt University, Hasselt, Belgium4. Biomedical NMR Unit, KU Leuven, Leuven, Belgium5. Laboratory of Radiopharmacy, KU Leuven, Leuven, Belgium6. Division of Nuclear Medicine, UZ Leuven, Herestraat 49, E901, 3000 Leuven, Belgium
• ISSN：1619-7089

文摘

Purpose Recent ex vivo and pharmacological evidence suggests involvement of the endocannabinoid system in the pathophysiology of stroke, but conflicting roles for type 1 and 2 cannabinoid receptors (CB₁ and CB₂) have been suggested. The purpose of this study was to evaluate CB₁ and CB₂ receptor binding over time in vivo in a rat photothrombotic stroke model using PET.