TLR2 2258 G>A single nucleotide polymorphism and the risk of congenital infection with human cytomegalovirus

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• 作者：Wioletta Wujcicka ; Edyta Paradowska ; Mirosława Studzińska…
• 关键词：Human cytomegalovirus (HCMV) ; Toll ; like receptor 2 (TLR2) ; Congenital cytomegaly ; Pregnancy ; Single nucleotide polymorphism (SNP)
• 刊名：Virology Journal
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：1433KB
• 刊物主题：Virology;
• 出版者：BioMed Central
• ISSN：1743-422X
• 卷排序：14

文摘

BackgroundHuman cytomegalovirus (HCMV) is responsible for the most common intrauterine infections, which may be acquired congenitally from infected pregnant woman to fetus. The research was aimed to estimate the role of three single nucleotide polymorphisms (SNPs) located in TLR2 gene, and the common contribution of TLR2, and previously studied TLR4 and TLR9 SNPs, to the occurrence of congenital HCMV infection in fetuses and newborns.