Frequency-specific stimulations induce reconsolidation of long-term potentiation in freely moving rats

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• 作者：Reiko Okubo-Suzuki ; Yoshito Saitoh ; Mohammad Shehata ; Qi Zhao…
• 关键词：Reconsolidation ; Long ; term potentiation ; Theta stimulation ; NMDA receptors
• 刊名：Molecular Brain
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：1
• 全文大小：2,490 KB
• 刊物主题：Neurosciences; Neurology;
• 出版者：BioMed Central
• ISSN：1756-6606

文摘

Background When consolidated memories are retrieved, they become labile and a new protein synthesis-dependent reconsolidation process is required to restabilize these memories. So far, most studies conducted on reconsolidation rely on the analyses of animal behavior, leaving the synaptic mechanisms that underlie reconsolidation largely unclear. Here, we examined whether the reconsolidation process occurs in hippocampal long term potentiation (LTP), as a synaptic model that is correlated with long term memories (LTM).