Nanomaterial Applications in Multiple Sclerosis Inflamed Brain
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- 作者：Clara Ballerini (1)
Giovanni Baldi (2)
Alessandra Aldinucci (1)
Pietro Maggi (3) (4)
1. Department of Neurofarba ; University of Florence ; Viale Pieraccini ; 6 ; 50137 ; Florence ; Italy
2. Ce.Ri.Col -Research Center Colorobbia ; Montelupo Fiorentino ; Florence ; Italy
3. H么pital Erasme -Universit茅 libre de Bruxelles -Bruxelles-Be ; Brussels ; Belgium
4. National Institute of Neurological Disorders and Stroke -NIH-Bethesda-US ; Bethesda ; MD ; USA - 关键词：Nanotechnology ; Nanomaterials ; Imaging ; Therapy ; Brain inflammation ; Multiple sclerosis
- 刊名：Journal of Neuroimmune Pharmacology
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：10
- 期：1
- 页码：1-13
- 全文大小：835 KB
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- 出版者：Springer US
- ISSN：1557-1904
文摘
In the last years scientific progress in nanomaterials, where size and shape make the difference, has increased their utilization in medicine with the development of a promising new translational science: nanomedicine. Due to their surface and core biophysical properties, nanomaterials hold the promise for medical applications in central nervous system (CNS) diseases: inflammatory, degenerative and tumors. The present review is focused on nanomaterials at the neuro-immune interface, evaluating two aspects: the possible CNS inflammatory response induced by nanomaterials and the developments of nanomaterials to improve treatment and diagnosis of neuroinflammatory diseases, with a focus on multiple sclerosis (MS). Indeed, nanomedicine allows projecting new ways of drug delivery and novel techniques for CNS imaging. Despite the wide field of application in neurological diseases of nanomaterials, our topic here is to review the more recent development of nanomaterials that cross blood brain barrier (BBB) and reach specific target during CNS inflammatory diseases, a crucial strategy for CNS early diagnosis and drug delivery, indeed the main challenges of nanomedicine.