Insulin Resistance in Young Obese Subjects and Its Relation to Smoking (A Pilot Study)
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- 作者：Aarzoo Juneja ; Shridhar Dwivedi…
- 关键词：Cardiovascular disease (CVD) ; Fasting blood glucose (FBG) ; Homeostatic model assessment of insulin resistance (HOMA ; IR) ; Insulin resistance (IR) ; Short term studentship (STS) ; Type 2 diabetes mellitus (T2DM) ; Triglyceride (TG) ; Jun amino ; terminal kinases (JNK)
- 刊名：Indian Journal of Clinical Biochemistry
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：32
- 期：1
- 页码：99-102
- 全文大小：
- 刊物主题：Biochemistry, general; Microbiology; Chemistry/Food Science, general; Pathology;
- 出版者：Springer India
- ISSN：0974-0422
- 卷排序：32
文摘
Insulin resistance is a condition in which cells fail to respond to the normal actions of insulin. Dietary fat, obesity and smoking have been attributed to increase insulin resistance. However, the prevalence of insulin resistance in young obese subjects and its relation to smoking is not well established. This study comprising seventy-five healthy young adults was undertaken to find insulin resistance in obese smokers and non smokers both. Present study showed an overall prevalence of raised homeostatic model assessment of insulin resistance in 14.7 % otherwise healthy young subjects (20–30 years age group). Non-smokers did not show any significant correlation between insulin resistance and body mass index at either stage (normal, pre-obese as well as obese). Smokers also did not show any significant difference of insulin resistance in normal and pre-obese stages. However, marked increase in homeostatic model assessment of insulin resistance was observed in obese smokers. Homeostatic model assessment of insulin resistance showed a linear trend in relation to body mass index and its values were found to be higher in smokers. Obesity combined with smoking demonstrated statistically significant increase in homeostatic model assessment of insulin resistance.