SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes
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- 作者：Weier Qi ; Qian Li ; Chong Wee Liew ; Christian Rask-Madsen…
- 关键词：Diabetes ; Insulin resistance ; Restenosis ; SHP ; 1
- 刊名：Diabetologia
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：60
- 期：3
- 页码：585-596
- 全文大小：3386KB
- 刊物类别：Medicine
- 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0428
- 卷排序：60
文摘
Aims/hypothesisAccelerated migration and proliferation of vascular smooth muscle cells (VSMCs) enhances arterial restenosis after angioplasty in insulin resistance and diabetes. Elevation of Src homology 2-containing protein tyrosine phosphatase 1 (SHP-1) induces apoptosis in the microvasculature. However, the role of SHP-1 in intimal hyperplasia and restenosis has not been clarified in insulin resistance and diabetes.