Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer

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• 作者：Hannah R. Wardill ; Richard M. Logan ; Joanne M. Bowen…
• 关键词：Mucositis ; Chemotherapy ; Oral toxicity ; Tight junctions ; Clinical ; Oral mucosa
• 刊名：Supportive Care in Cancer
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：24
• 期：4
• 页码：1779-1788
• 全文大小：2,619 KB
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• 作者单位：Hannah R. Wardill (1)
  Richard M. Logan (2)
  Joanne M. Bowen (3)
  Ysabella Z. A. Van Sebille (3)
  Rachel J. Gibson (1)
  
  1. Discipline of Anatomy and Pathology, School of Medicine, University of Adelaide, North Terrace, Adelaide, South Australia, 5005, Australia
  2. School of Dentistry, University of Adelaide, Adelaide, South Australia, Australia
  3. Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Nursing
  Nursing Management and Research
  Pain Medicine
  Rehabilitation Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-7339

文摘

Purpose Oral mucositis is one of the most common and debilitating side effects of chemotherapy treatment. Patients are often unable to eat and drink, which can lead to poor clinical outcomes and extensive resource utilisation. The primary aim of this study was to determine the molecular integrity of oral epithelial tight junctions in patients undergoing chemotherapy. The secondary aim was to correlate these changes with proinflammatory cytokines and matrix metalloproteinase profiles.