Gradient compression garments protect against orthostatic intolerance during recovery from bed rest

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• 作者：Michael B. Stenger (1)
  Stuart M. C. Lee (1)
  L. Christine Ribeiro (1)
  Tiffany R. Phillips (1)
  Robert J. Ploutz-Snyder (2)
  Michael C. Willig (3)
  Christian M. Westby (2)
  Steven H. Platts (4)
  
• 关键词：Spaceflight ; Countermeasure ; Anti ; gravity suit ; Tilt test ; Presyncope
• 刊名：European Journal of Applied Physiology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：114
• 期：3
• 页码：597-608
• 全文大小：653 KB
• 作者单位：Michael B. Stenger (1)
  Stuart M. C. Lee (1)
  L. Christine Ribeiro (1)
  Tiffany R. Phillips (1)
  Robert J. Ploutz-Snyder (2)
  Michael C. Willig (3)
  Christian M. Westby (2)
  Steven H. Platts (4)
  
  1. Wyle Science, Technology and Engineering Group, 1290 Hercules Ave, Houston, TX, 77058, USA
  2. Universities Space Research Association, Houston, TX, USA
  3. JES Tech, Houston, TX, USA
  4. Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA
  
• ISSN：1439-6327

文摘

Introduction Abdomen-high, lower body graded compression garments (GCGs) may represent the next-generation of orthostatic intolerance protection with applications for exploration missions and commercial space flight. Purpose To evaluate the efficacy of the GCG to prevent orthostatic intolerance after a 14-day 6° head-down tilt bed rest (BR) and to determine whether wearing thigh-high compression garments impairs recovery from BR. Methods Sixteen (12 M, 4 F) subjects participated in a 15-min 80° head-up tilt test 5?day before BR (BR-5), on the last morning of BR (BR+0), and on day 1 (BR+1) and 3 after BR (BR+3). No subjects wore the GCG on BR-5, and all subjects wore the GCG during testing on BR+0. Control subjects (n?=?8) wore the GCG only through testing on BR+0. Treatment subjects (n?=?8) wore the GCG on BR+0 and thigh-high garments on BR+1 and BR+2. Results No subjects were presyncopal during tilt on BR+0 while wearing the GCG. Despite lower plasma volume index (BR-5: 1.52?±?0.06, BR+0: 1.32?±?0.05?l/m2), the tilt-induced increase in heart rate (ΔHR, 17?±?2?bpm) and decrease in stroke volume (ΔSV, ?8?±?3?ml) on BR+0 were less than on BR-5 (24?±?2?bpm, ?3?±?4?ml). On BR+1 ΔHR in the control group (33?±?4?bpm) was higher than in the treatment group (23?±?2?bpm) but there were no group differences on BR+3. Conclusions Wearing the GCG prevented the orthostatic intolerance that is normally present after BR. Thigh-high garments provided protection after BR, and wearing these garments did not impair recovery.