Elastic properties of woven bone: effect of mineral content and collagen fibrils orientation

详细信息    查看全文

• 作者：J. García-Rodríguez ; J. Martínez-Reina
• 关键词：Woven bone ; Multiscale micromechanical model ; Homogenization ; Mineral content
• 刊名：Biomechanics and Modeling in Mechanobiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：16
• 期：1
• 页码：159-172
• 全文大小：
• 刊物类别：Engineering
• 刊物主题：Theoretical and Applied Mechanics; Biomedical Engineering; Biological and Medical Physics, Biophysics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1617-7940
• 卷排序：16

文摘

Woven bone is a type of tissue that forms mainly during fracture healing or fetal bone development. Its microstructure can be modeled as a composite with a matrix of mineral (hydroxyapatite) and inclusions of collagen fibrils with a more or less random orientation. In the present study, its elastic properties were estimated as a function of composition (degree of mineralization) and fibril orientation. A self-consistent homogenization scheme considering randomness of inclusions’ orientation was used for this purpose. Lacuno-canalicular porosity in the form of periodically distributed void inclusions was also considered. Assuming collagen fibrils to be uniformly oriented in all directions led to an isotropic tissue with a Young’s modulus \(E = 1.90\) GPa, which is of the same order of magnitude as that of woven bone in fracture calluses. By contrast, assuming fibrils to have a preferential orientation resulted in a Young’s modulus in the preferential direction of 9–16 GPa depending on the mineral content of the tissue. These results are consistent with experimental evidence for woven bone in foetuses, where collagen fibrils are aligned to a certain extent.