Characterization of ovarian clear cell carcinoma using target drug-based molecular biomarkers: implications for personalized cancer therapy

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• 作者：Mengjiao Li ; Haoran Li ; Fei Liu ; Rui Bi ; Xiaoyu Tu…
• 关键词：Ovarian clear cell carcinoma ; Immunohistochemistry ; Chemoresistance ; Aurora kinase A ; Programmed death ligand ; 1
• 刊名：Journal of Ovarian Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：5006KB
• 刊物主题：Gynecology; Reproductive Medicine;
• 出版者：BioMed Central
• ISSN：1757-2215
• 卷排序：10

文摘

BackgroundIt has long been appreciated that different subtypes (serous, clear cell, endometrioid and mucinous) of epithelial ovarian carcinoma (EOC) have distinct pathogenetic pathways. However, clinical management, especially chemotherapeutic regimens, for EOC patients is not subtype specific. Ovarian clear cell carcinoma (CCC) is a rare histological subtype of EOC, which exhibits high rates of recurrence and low chemosensitivity. We assessed potential therapeutic targets for ovarian CCC patients through analyzing the variation of drug-based molecular biomarkers expression between ovarian CCC and high-grade serous carcinoma (HGSC).