Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models

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• 作者：Hyung Sook Kim ; Hwa Sun Ryu ; Ji Sung Kim ; Yong Guk Kim…
• 关键词：4 ; O ; methylhonokiol ; Cyclooxygenase ; 2 ; Anti ; inflammatory target
• 刊名：Archives of Pharmacal Research
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：38
• 期：5
• 页码：813-825
• 全文大小：829 KB
• 参考文献：Ashton, J.C., and M. Glass. 2007. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Current Neuropharmacology 5: 73-0.View Article PubMed Central PubMed
  Bombardier, C., L. Laine, A. Reicin, D. Shapiro, R. Burgos-Vargas, B. Davis, R. Day, M.B. Ferraz, C.J. Hawkey, M.C. Hochberg, T.K. Kvien, T.J. Schnitzer, and V.S. Group. 2000. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. New England Journal of Medicine 343: 1520-528. 1522 p following 1528.View Article PubMed
  Bresalier, R.S., R.S. Sandler, H. Quan, J.A. Bolognese, B. Oxenius, K. Horgan, C. Lines, R. Riddell, D. Morton, A. Lanas, M.A. Konstam, J.A. Baron, and Adenomatous Polyp Prevention on Vioxx Trial, I. 2005. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. New England Journal of Medicine 352: 1092-102.View Article PubMed
  Chao, L.K., P.C. Liao, C.L. Ho, E.I. Wang, C.C. Chuang, H.W. Chiu, L.B. Hung, and K.F. Hua. 2010. Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kappaB pathway to reduce LPS-induced TNFalpha and NO expression. Journal of Agriculture and Food Chemistry 58: 3472-478.View Article
  Choi, I.S., Y.J. Lee, D.Y. Choi, Y.K. Lee, Y.H. Lee, K.H. Kim, Y.H. Kim, Y.H. Jeon, E.H. Kim, S.B. Han, J.K. Jung, Y.P. Yun, K.W. Oh, D.Y. Hwang, and J.T. Hong. 2011. 4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-beta generation and accumulation in a mouse model of Alzheimer’s disease. Journal of Alzheimer’s Disease 27: 127-41.PubMed
  Choi, M.S., S.H. Lee, H.S. Cho, Y. Kim, Y.P. Yun, H.Y. Jung, J.K. Jung, B.C. Lee, H.B. Pyo, and J.T. Hong. 2007. Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappaB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells. European Journal of Pharmacology 556: 181-89.View Article PubMed
  Coxib, Traditional, N.T.C, N. Bhala, J. Emberson, A. Merhi, S. Abramson, N. Arber, J.A. Baron, C. Bombardier, C. Cannon, M.E. Farkouh, G.A. Fitzgerald, P. Goss, H. Halls, E. Hawk, C. Hawkey, C. Hennekens, M. Hochberg, L.E. Holland, P.M. Kearney, L. Laine, A. Lanas, P. Lance, A. Laupacis, J. Oates, C. Patrono, T.J. Schnitzer, S. Solomon, P. Tugwell, K. Wilson, J. Wittes, and C. Baigent. 2013. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet 382: 769-79.View Article
  Fitzgerald, G.A., and C. Patrono. 2001. The coxibs, selective inhibitors of cyclooxygenase-2. New England Journal of Medicine 345: 433-42.View Article PubMed
  Fu, Y., B. Liu, N. Zhang, Z. Liu, D. Liang, F. Li, Y. Cao, X. Feng, X. Zhang, and Z. Yang. 2013. Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-kappaB and MAPKs signaling pathways. Journal of Ethnopharmacology 145: 193-99.View Article PubMed
  Fuchs, A., V. Rempel, and C.E. Muller. 2013. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One 8: e77739.View Article PubMed Central PubMed
  Han, H., J.K. Jung, S.B. Han, S.Y. Nam, K.W. Oh, and J.T. Hong. 2011. Anxiolytic-like effects of 4-O-methylhonokiol isolated from Magnolia officinalis through enhancement of GABAergic transmission and chloride influx. Journal of Medicinal Food 14: 724-31.View Article PubMed
  Han, S.B., C.W. Lee, Y.D. Yoon, J.H. Lee, J.S. Kang, K.H. Lee, W.K. Yoon, K. Lee, S.K. Park, and H.M. Kim. 2005. Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica. Archives of Pharmacal Research 28: 902-08.View Article PubMed
  Ibrahim, T., J.M. Cunha, K. Madi, L.M. Da Fonseca, S.S. Costa, and V.L. Goncalves Koatz. 2002. Immunomodulatory and anti-inflammatory effects of Kalanchoe brasiliensis. International Immunopharmacology 2: 875-83.View Article PubMed
  Inotai, A., B. Hanko, and A. Meszaros. 2010. Trends in the non-steroidal anti-inflammatory drug market in six Central-Eastern European countries based on retail information. Pharmacoepidemiology and Drug Safety 19: 183-90.View Article PubMed
  Kim, H.S., J.Y. Kim, H.S. Ryu, H.G. Park, Y.O. Kim, J.S. Kang, H.M. Kim, J.T. Hong, Y. Kim, and S.B. Han. 2010. Induction of dendritic cell maturation by beta-glucan isolated from Sparassis crispa. International Immunopharmacology 10: 1284-294.View Article PubMed
  Kim, H.S., B.R. Shin, H.K. Lee, Y.S. Park, Q. Liu, S.Y. Kim, M.K. Lee, J.T. Hong, Y. Kim, and S.B. Han. 2013a. Dendritic cell activation by polysaccharide isolated from Angelica dahurica. Food and Chemical Toxicology 55: 241-47.View Article PubMed
  Kim, J.Y., H.S. Kim, Y.J. Kim, H.K. Lee, J.S. Kim, J.S.
• 作者单位：Hyung Sook Kim (1)
  Hwa Sun Ryu (1)
  Ji Sung Kim (1)
  Yong Guk Kim (1)
  Hong Kyung Lee (1)
  Jae Kyung Jung (1)
  Young Shin Kwak (2)
  Kiho Lee (2)
  Seung Yong Seo (3)
  Jieun Yun (4)
  Jong Soon Kang (4)
  Jin Tae Hong (1)
  Youngsoo Kim (1)
  Sang-Bae Han (1)
  
  1. College of Pharmacy, Chungbuk National University, 52 Naesoodong, Heungduk, Cheongju, Chungbuk, 361-763, South Korea
  2. College of Pharmacy, Korea University, Sejong, 339-700, South Korea
  3. College of Pharmacy, Gachon University, Inchon, 406-779, South Korea
  4. Korean Research Institute of Bioscience and Biotechnology, Ochang, Chungbuk, 363-883, South Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

4-O-methylhonokiol (MH) is known to inhibit inflammation by partially understood mechanisms. Here, the anti-inflammatory mechanisms of MH were examined using enzymatic, cellular, and animal assays. In enzymatic assays, MH inhibited COX-2 activity with an IC<sub>50sub> of 0.062?μM, and also COX-1 with an IC<sub>50sub> of 2.4?μM. In cellular assays, MH was immunotoxic above 10?μM. At non-toxic concentrations (below 3?μM), MH strongly inhibited COX-2-mediated prostaglandin production with an IC<sub>50sub> of 0.1?μM, whereas did not or slightly affect other functions of B cells, T cells, dendritic cells, and macrophages. In an animal model, MH inhibited the increase in footpad thickness and popliteal lymph node weight in zymosan-injected mice. When analyzed the draining pLNs of zymosan-injected mice on day 5, MH inhibited the overall inflammatory responses. However, MH inhibited cyclooxygenase (COX)-2-mediated prostaglandin production without affecting tumor necrosis factor-α production in inflamed tissues within 6?h after zymosan injection. In summary, our data suggest that COX-2 may be a direct anti-inflammatory target of MH in vitro and in vivo.