A rare case of multiple phosphaturic mesenchymal tumors along a tendon sheath inducing osteomalacia

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• 作者：Ryuta Arai ; Tomohiro Onodera ; Mohamad Alaa Terkawi…
• 关键词：Tumor ; induced osteomalacia ; Multiple phosphaturic mesenchymal tumor ; Fibroblast growth factor 23 ; Hypophosphatemia ; Systemic venous sampling ; Case report
• 刊名：BMC Musculoskeletal Disorders
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1183KB
• 刊物主题：Orthopedics; Rehabilitation; Rheumatology; Sports Medicine; Internal Medicine; Epidemiology;
• 出版者：BioMed Central
• ISSN：1471-2474
• 卷排序：18

文摘

BackgroundTumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors associated with TIO are typically phosphaturic mesenchymal tumors that are bone and soft tissue origin and often present as a solitary tumor. The high production of fibroblast growth factor 23 (FGF23) by the tumor is believed to be the causative factor responsible for the impaired renal tubular phosphate reabsorption, hypophosphatemia and osteomalacia. Complete removal of the tumors by surgery is the most effective procedure for treatment. Identification of the tumors by advanced imaging techniques is difficult because TIO is small and exist within bone and soft tissue. However, systemic venous sampling has been frequently reported to be useful for diagnosing TIO patients.