Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40

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• 作者：Prasanna Karki (1) (2)
  Takashi Kurihara (2)
  Tomoya Nakamachi (3) (4)
  Jun Watanabe (3)
  Toshihide Asada (2)
  Tatsuki Oyoshi (1)
  Seiji Shioda (3)
  Megumu Yoshimura (5)
  Kazunori Arita (1)
  Atsuro Miyata (2)
  
  1. Department of Neurosurgery ; Graduate School of Medical and Dental Sciences ; Kagoshima University ; 8-35-1 Sakuragaoka ; Kagoshima City ; Kagoshima ; 890-8544 ; Japan
  2. Department of Pharmacology ; Graduate School of Medical and Dental Sciences ; Kagoshima University ; 8-35-1 Sakuragaoka ; Kagoshima City ; Kagoshima ; 890-8544 ; Japan
  3. Department of Anatomy ; Showa University ; School of Medicine ; 1-5-8 Hatanodai ; Shinagawa-ku ; Tokyo ; 142-8555 ; Japan
  4. Laboratory of Regulatory Biology ; Graduate School of Science and Engineering ; University of Toyama ; 3190-Gofuku ; Toyama ; 930-8555 ; Japan
  5. Graduate School of Health Sciences ; Kumamoto Health Science University ; 325 Izumi-machi ; Kumamoto ; 861-5598 ; Japan
  
• 关键词：Allodynia ; Carrageenan ; Complete Freund鈥檚 adjuvant ; FFA1 ; FFAR1 ; Hyperalgesia ; Spinal cord ; Spinal nerve ligation ; Whole ; cell patch ; clamp
• 刊名：Molecular Pain
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：11
• 期：1
• 全文大小：4,002 KB
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• 刊物主题：Pain Medicine; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：1744-8069

文摘

Background The G-protein-coupled receptor 40 (GPR40) is suggested to function as a transmembrane receptor for medium- to long-chain free fatty acids and is implicated to play a role in free fatty acids-mediated enhancement of glucose-stimulated insulin secretion from pancreas. However, the functional role of GPR40 in nervous system including somatosensory pain signaling has not been fully examined yet. Results Intrathecal injection of GPR40 agonist (MEDICA16 or GW9508) dose-dependently reduced ipsilateral mechanical allodynia in CFA and SNL models and thermal hyperalgesia in carrageenan model. These anti-allodynic and anti-hyperalgesic effects were almost completely reversed by a GPR40 antagonist, GW1100. Immunohistochemical analysis revealed that GPR40 is expressed in spinal dorsal horn and dorsal root ganglion neurons, and immunoblot analysis showed that carrageenan or CFA inflammation or spinal nerve injury resulted in increased expression of GPR40 in these areas. Patch-clamp recordings from spinal cord slices exhibited that bath-application of either MEDICA16 or GW9508 significantly decreased the frequency of spontaneous excitatory postsynaptic currents in the substantia gelatinosa neurons of the three pain models. Conclusions Our results indicate that GPR40 signaling pathway plays an important suppressive role in spinal nociceptive processing after inflammation or nerve injury, and that GPR40 agonists might serve as a new class of analgesics for treating inflammatory and neuropathic pain.