TSHR intronic polymorphisms (rs179247 and rs12885526) and their role in the susceptibility of the Brazilian population to Graves鈥?disease and Graves鈥?ophthalmopathy

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• 作者：N. E. Bufalo ; R. B. dos Santos ; M. A. Marcello…
• 关键词：Autoimmunity ; Graves鈥?disease ; Thyroid ; stimulating hormone receptor ; Polymorphisms
• 刊名：Journal of Endocrinological Investigation
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：38
• 期：5
• 页码：555-561
• 全文大小：
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• 作者单位：N. E. Bufalo (1) r> R. B. dos Santos (2) r> M. A. Marcello (1) r> R. P. Piai (1) r> R. Secolin (3) r> J. H. Romaldini (2) (4) r> L. S. Ward (1) r>r>1. Laboratory of Cancer Molecular Genetics, School of Medical Sciences (FCM), University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, SP, 13083-887, Brazil r> 2. Division of Endocrinology, Pontifical Catholic University of Campinas (PUCCAMP), Av. John Boyd Dunlop, s/no Jardim Ipaussurama, Campinas, SP, 13060-904, Brazil r> 3. Department of Medical Genetics, University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria Zeferino Vaz, Campinas, SP, 13083-887, Brazil r> 4. HSPE-IAMSPE, Av. Ibirapuera, 981, Vila Clementino, S茫o Paulo, 04029-000, Brazil r>
• 刊物类别：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 刊物主题：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 出版者：Springer International Publishing
• ISSN：1720-8386

文摘

Purpose Intronic thyroid-stimulating hormone receptor polymorphisms have been associated with the risk for both Graves鈥?disease and Graves鈥?ophthalmopathy, but results have been inconsistent among different populations. We aimed to investigate the influence of thyroid-stimulating hormone receptor intronic polymorphisms in a large well-characterized population of GD patients.