Synthesis of biogenic gold nano conjugate for increased efficacy and sustained drug release profile of saquinavir
- Rohan Kesarkar,
- Sweta Kothari,
- Abhay Chowdhary
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Background
Conventional anti retroviral treatment (ART) has been a core treatment for HIV over the past three decades. Despite the effectiveness of these drugs, most of them abide significant drawbacks such as poor bioavailability and undesirable side effects; thus reducing patient compliance and rendering treatment regime ineffective. This research work is an attempt to develop a dual pronged carrier system using gold nanoparticles (GNP) for increasing effectiveness and sustained drug release of saquinavir.
Methods
Leaf extract of / Azadirachta indica was used as an efficient sink for synthesis of GNPs by microwave assistance. Saquinavir (Saq) was attached onto GNPs that were pre functionalized by capping polypeptide linkers of / A.indica and characterized by FTIR. Percentage drug loading efficiency (%DLE) and release kinetics were studied by statistical model dependent method. Biocompatibility of drug nanoparticle conjugate was studied by MTT assay. Antiviral efficacy was assessed by quanti
Within this Article
- Background
- 作者单位:Rohan Kesarkar (93)
Sweta Kothari (93)
Abhay Chowdhary (93)
93. Department of Virology and Immunology, Haffkine Institute for Training Research and Testing, Mumbai, 400012, India - ISSN:1471-2334
Methods
Results
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