Inflammatory protein response in CDKL5-Rett syndrome: evidence of a subclinical smouldering inflammation

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• 作者：Alessio Cortelazzo ; Claudio de Felice ; Silvia Leoncini…
• 关键词：Rett syndrome ; Cyclin ; dependent kinase ; like 5 ; Subclinical inflammation ; Acute ; phase proteins ; Polyunsaturated fatty acids ; Cytokines
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：66
• 期：3
• 页码：269-280
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

BackgroundMutations in the cyclin-dependent kinase-like 5 gene cause a clinical variant of Rett syndrome (CDKL5-RTT). A role for the acute-phase response (APR) is emerging in typical RTT caused by methyl-CpG-binding protein 2 gene mutations (MECP2-RTT). No information is, to date, available on the inflammatory protein response in CDKL5-RTT. We evaluated, for the first time, the APR protein response in CDKL5-RTT.