Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
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- 作者：Cameron Lindsay ; Hadi Seikaly…
- 关键词：Oropharyngeal cancer ; Human papillomavirus ; Squamous cell carcinoma ; Epigenetics ; Chemotherapy
- 刊名：Journal of Otolaryngology - Head & Neck Surgery
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：46
- 期：1
- 全文大小：660KB
- 刊物主题：Otorhinolaryngology; Head and Neck Surgery; Plastic Surgery; Oral and Maxillofacial Surgery;
- 出版者：BioMed Central
- ISSN：1916-0216
- 卷排序：46
文摘
Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-coding RNAs. Alterations in epigenetic profiles cause deregulation of fundamental gene expression pathways associated with carcinogenesis. The role of epigenetics in oropharyngeal squamous cell carcinoma (OPSCC) has recently been recognized, with implications for novel biomarkers, molecular diagnostics and chemotherapeutics. In this review, important epigenetic pathways in human papillomavirus (HPV) positive and negative OPSCC are summarized, as well as the potential clinical utility of this knowledge.