Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats
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- 作者：Nur Shafika Mohd Sairazi ; Sirajudeen K.N.S.…
- 关键词：Tualang honey ; Kainic acid ; Neurodegeneration ; Oxidative stress ; Behavioral change ; Fluoro Jade C ; Cresyl violet
- 刊名：BMC Complementary and Alternative Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：3772KB
- 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
- 出版者：BioMed Central
- ISSN：1472-6882
- 卷排序：17
文摘
BackgroundAdministration of KA on rodents has resulted in seizures, behavioral changes, oxidative stress, and neuronal degeneration on selective population of neurons in the brain. The present study was undertaken to investigate the extent of neuroprotective effect conferred by Malaysian Tualang Honey (TH), an antioxidant agent, in the cerebral cortex of rats against KA-induced oxidative stress and neurodegeneration in an animal model of KA-induced excitotoxicity.