A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients
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- 作者：Shinichi Honda ; Tomohiro Nakao ; Hiroshi Mitsuyasu…
- 关键词：Hippocampus ; Precentral gyrus ; Frontal pole ; Imaging genetics ; Obsessive ; compulsive disorder (OCD) ; Serotonin transporter gene ; 5 ; HTTLPR ; Voxel ; based morphometry (VBM)
- 刊名：Annals of General Psychiatry
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1005KB
- 刊物主题：Psychiatry; Psychopharmacology; Forensic Psychiatry;
- 出版者：BioMed Central
- ISSN：1744-859X
- 卷排序：16
文摘
BackgroundClinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables.