CD14^brightCD16+ intermediate monocytes are induced by interleukin-10 and positively correlate with disease activity in rheumatoid arthritis

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• 作者：Masako Tsukamoto ; Noriyuki Seta ; Keiko Yoshimoto…
• 关键词：Rheumatoid Arthritis ; Monocytes ; Interleukin ; 10 ; CD16
• 刊名：Arthritis Research & Therapy
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：1054KB
• 刊物主题：Rheumatology; Orthopedics;
• 出版者：BioMed Central
• ISSN：1478-6362
• 卷排序：19

文摘

BackgroundThree different subsets of circulating human monocytes, CD14brightCD16- (classical), CD14brightCD16+ (intermediate), and CD14dimCD16+ (non-classical) have been recently identified. It has been reported that CD14brightCD16+ monocytes are increased in rheumatoid arthritis (RA). However, the role of each monocyte subset in the pathogenesis of RA is still unclear. The purpose of this study was to investigate the association of CD14brightCD16+ monocytes with RA.