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Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice
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  • 作者:Shanshan Geng ; Weiwei Zhu ; Chunfeng Xie ; Xiaoting Li…
  • 关键词:Medium ; chain triglyceride ; Insulin resistance ; Inflammation ; NF ; κB ; p38 MAPK
  • 刊名:European Journal of Nutrition
  • 出版年:2016
  • 出版时间:April 2016
  • 年:2016
  • 卷:55
  • 期:3
  • 页码:931-940
  • 全文大小:817 KB
  • 参考文献:1.Li Q, Zhong W, Qiu Y, Kang X, Sun X, Tan X, Zhao Y, Sun X, Jia W, Zhou Z (2013) Preservation of hepatocyte nuclear factor-4alpha contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats. Alcohol Clin Exp Res 37:587–598CrossRef
    2.Shinohara H, Wu J, Aoyama T (2010) Effect of randomly interesterified triacylglycerol containing medium- and long-chain fatty acids on hepatic fatty acid oxidation after a single administration to rats. Biosci Biotechnol Biochem 74:2336–2338CrossRef
    3.Shinohara H, Wu J, Kasai M, Aoyama T (2006) Randomly interesterified triacylglycerol containing medium- and long-chain fatty acids stimulates fatty acid metabolism in white adipose tissue of rats. Biosci Biotechnol Biochem 70:2919–2926CrossRef
    4.Shinohara H, Ogawa A, Kasai M, Aoyama T (2005) Effect of randomly interesterified triacylglycerols containing medium- and long-chain fatty acids on energy expenditure and hepatic fatty acid metabolism in rats. Biosci Biotechnol Biochem 69:1811–1818CrossRef
    5.Takeuchi H, Sekine S, Kojima K, Aoyama T (2008) The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation. Asia Pac J Clin Nutr 17(Suppl 1):320–323
    6.St-Onge MP, Ross R, Parsons WD, Jones PJ (2003) Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Obes Res 11:395–402CrossRef
    7.St-Onge MP, Jones PJ (2003) Greater rise in fat oxidation with medium-chain triglyceride consumption relative to long-chain triglyceride is associated with lower initial body weight and greater loss of subcutaneous adipose tissue. Int J Obes Relat Metab Disord 27:1565–1571CrossRef
    8.Nosaka N, Maki H, Suzuki Y, Haruna H, Ohara A, Kasai M, Tsuji H, Aoyama T, Okazaki M, Igarashi O, Kondo K (2003) Effects of margarine containing medium-chain triacylglycerols on body fat reduction in humans. J Atheroscler Thromb 10:290–298CrossRef
    9.St-Onge MP, Bosarge A, Goree LL, Darnell B (2008) Medium chain triglyceride oil consumption as part of a weight loss diet does not lead to an adverse metabolic profile when compared to olive oil. J Am Coll Nutr 27:547–552CrossRef
    10.Bourque C, St-Onge MP, Papamandjaris AA, Cohn JS, Jones PJ (2003) Consumption of an oil composed of medium chain triacyglycerols, phytosterols, and N-3 fatty acids improves cardiovascular risk profile in overweight women. Metabolism 52:771–777CrossRef
    11.Ronis MJ, Baumgardner JN, Sharma N, Vantrease J, Ferguson M, Tong Y, Wu X, Cleves MA, Badger TM (2013) Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease. Exp Biol Med (Maywood) 238:151–162CrossRef
    12.Zhao W, Varghese M, Vempati P, Dzhun A, Cheng A, Wang J, Lange D, Bilski A, Faravelli I, Pasinetti GM (2012) Caprylic triglyceride as a novel therapeutic approach to effectively improve the performance and attenuate the symptoms due to the motor neuron loss in ALS disease. PLoS One 7:e49191CrossRef
    13.Carlson SJ, Nandivada P, Chang MI, Mitchell PD, O’Loughlin A, Cowan E, Gura KM, Nose V, Bistrian BR, Puder M (2015) The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice. Metabolism 64:274–282CrossRef
    14.Kono H, Fujii H, Ogiku M, Tsuchiya M, Ishii K, Hara M (2010) Enteral diets enriched with medium-chain triglycerides and N-3 fatty acids prevent chemically induced experimental colitis in rats. Transl Res 156:282–291CrossRef
    15.Mane J, Pedrosa E, Loren V, Ojanguren I, Fluvia L, Cabre E, Rogler G, Gassull MA (2009) Partial replacement of dietary (n-6) fatty acids with medium-chain triglycerides decreases the incidence of spontaneous colitis in interleukin-10-deficient mice. J Nutr 139:603–610CrossRef
    16.Hoshimoto A, Suzuki Y, Katsuno T, Nakajima H, Saito Y (2002) Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. Br J Pharmacol 136:280–286CrossRef
    17.Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29:415–445CrossRef
    18.Tanti JF, Ceppo F, Jager J, Berthou F (2012) Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne) 3:181
    19.Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191–198CrossRef
    20.Tanti JF, Jager J (2009) Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol 9:753–762CrossRef
    21.Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860–867CrossRef
    22.Boisramé-Helms J, Said A, Burban M, Delabranche X, Stiel L, Zobairi F, Hasselmann M, Schini-Kerth V, Toti F, Meziani F (2014) Medium-chain triglyceride supplementation exacerbates peritonitis-induced septic shock in rats: role on cell membrane remodeling. Shock 42:548–553CrossRef
    23.Boisramé-Helms J, Delabranche X, Klymchenko A, Drai J, Blond E, Zobairi F, Mely Y, Hasselmann M, Toti F, Meziani F (2014) Lipid emulsions differentially affect LPS-induced acute monocytes inflammation: in vitro effects on membrane remodeling and cell viability. Lipids 49:1091–1099CrossRef
    24.Terada S, Yamamoto S, Sekine S, Aoyama T (2012) Dietary intake of medium- and long-chain triacylglycerols ameliorates insulin resistance in rats fed a high-fat diet. Nutrition 28:92–97CrossRef
    25.Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W (2007) Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism 56:985–991CrossRef
    26.Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18:621–663CrossRef
    27.Basak S, Hoffmann A (2008) Crosstalk via the NF-kappaB signaling system. Cytokine Growth Factor Rev 19:187–197CrossRef
    28.Kyriakis JM, Avruch J (2012) Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev 92:689–737CrossRef
    29.Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G (2003) Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J 22:1313–1324CrossRef
    30.Kefaloyianni E, Gaitanaki C, Beis I (2006) ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts. Cell Signal 18:2238–2251CrossRef
    31.Harford KA, Reynolds CM, McGillicuddy FC, Roche HM (2011) Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue. Proc Nutr Soc 70:408–417CrossRef
    32.Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TF, Dragun D, Skurk T, Hauner H, Bluher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N (2008) T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 28:1304–1310CrossRef
    33.Espinola-Klein C, Gori T, Blankenberg S, Munzel T (2011) Inflammatory markers and cardiovascular risk in the metabolic syndrome. Front Biosci (Landmark Ed) 16:1663–1674CrossRef
    34.Tang FY, Pai MH, Chiang EP (2012) Consumption of high-fat diet induces tumor progression and epithelial-mesenchymal transition of colorectal cancer in a mouse xenograft model. J Nutr Biochem 23:1302–1313CrossRef
    35.Park H, Kim M, Kwon GT, Lim do Y, Yu R, Sung MK, Lee KW, Daily JW 3rd, Park JH (2012) A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. Mol Carcinog 51:869–880CrossRef
    36.Burgueno AL, Gianotti TF, Mansilla NG, Pirola CJ, Sookoian S (2013) Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1alpha in a rat model. Clin Sci (Lond) 124:53–63CrossRef
    37.Yao L, Herlea-Pana O, Heuser-Baker J, Chen Y, Barlic-Dicen J (2014) Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease. J Immunol Res 2014:181450CrossRef
    38.Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4–12
    39.Dinh CH, Szabo A, Camer D, Yu Y, Wang H, Huang XF (2015) Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet. Chem Biol Interact 229:1–8CrossRef
    40.Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183–190CrossRef
    41.Lin HL, Shen KP, Chang WT, Lin JC, An LM, Chen IJ, Wu BN (2013) Eugenosedin-A prevents high-fat diet increased adhesion molecules through inhibition of MAPK- and p65-mediated NF-kappaB pathway in rat model. J Pharm Pharmacol 65:300–309CrossRef
    42.Wang Z, Xue L, Guo C, Han B, Pan C, Zhao S, Song H, Ma Q (2012) Stevioside ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by downregulating the NF-kappaB pathway. Biochem Biophys Res Commun 417:1280–1285CrossRef
    43.Liu K, Zhao W, Gao X, Huang F, Kou J, Liu B (2012) Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKbeta and IRS-1 pathways. Atherosclerosis 223:350–358CrossRef
    44.Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, Jung DY, Ko HJ, Ong H, Kim JK, Mynatt R, Martin RJ, Keenan M, Gao Z, Ye J (2010) Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem 285:4637–4644CrossRef
    45.Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS (2006) Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci USA 103:10741–10746CrossRef
    46.Kuo LH, Tsai PJ, Jiang MJ, Chuang YL, Yu L, Lai KT, Tsai YS (2011) Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse. Diabetologia 54:168–179CrossRef
    47.Hemi R, Yochananov Y, Barhod E, Kasher-Meron M, Karasik A, Tirosh A, Kanety H (2011) p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance. Diabetes 60:1134–1145CrossRef
    48.Gao D, Nong S, Huang X, Lu Y, Zhao H, Lin Y, Man Y, Wang S, Yang J, Li J (2010) The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem 285:29965–29973CrossRef
    49.Xi L, Xiao C, Bandsma RH, Naples M, Adeli K, Lewis GF (2011) C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: role of mitogen-activated protein kinases. Hepatology 53:127–135CrossRef
  • 作者单位:Shanshan Geng (1)
    Weiwei Zhu (1)
    Chunfeng Xie (1)
    Xiaoting Li (1)
    Jieshu Wu (1)
    Zhaofeng Liang (1)
    Wei Xie (1)
    Jianyun Zhu (1)
    Cong Huang (1)
    Mingming Zhu (1)
    Rui Wu (1)
    Caiyun Zhong (1)

    1. Department of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China
  • 刊物类别:Chemistry and Materials Science
  • 刊物主题:Chemistry
    Nutrition
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1436-6215
文摘
Purpose The aim of the present study was to investigate the in vivo effects of dietary medium-chain triglyceride (MCT) on inflammation and insulin resistance as well as the underlying potential molecular mechanisms in high fat diet-induced obese mice.

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