Nuclear reprogramming by nuclear transplantation and defined transcription factors

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• 作者：YiXuan Wang (1)
  Sheng Liu (1)
  LiangXue Lai (2)
  ShaoRong Gao (1)
  
• 关键词：nuclear reprogramming ; somatic cell nuclear transfer (SCNT) ; induced pluripotent stem (iPS) cell
• 刊名：Chinese Science Bulletin
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：54
• 期：1
• 页码：14-18
• 全文大小：549KB
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• 作者单位：YiXuan Wang (1)
  Sheng Liu (1)
  LiangXue Lai (2)
  ShaoRong Gao (1)
  
  1. National Institute of Biological Sciences, Beijing, 102206, China
  2. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 5106603, China
  
• ISSN：1861-9541

文摘

In the past ten years, great breakthroughs have been achieved in the nuclear reprogramming area. It has been demonstrated that highly differentiated somatic cell genome could be reprogrammed to a pluripotent state, which indicates that differentiated cell fate is not irreversible. Nuclear transplantation and induced pluripotent stem (iPS) cell generation are the two major approaches to inducing reprogramming of differentiated somatic cell genome. In the present review, we will summarize the recent progress of nuclear reprogramming and further discuss the potential to generate patient specific pluripotent stem cells from differentiated somatic cells for therapeutic purpose.