Risk factors for primary lung cancer among never smokers by gender in a matched case–control study
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- 作者：Yen-Li Lo (1)
Chin-Fu Hsiao (1)
Gee-Chen Chang (2)
Ying-Huang Tsai (3)
Ming-Shyan Huang (4)
Wu-Chou Su (5)
Yuh-Min Chen (6)
Che-Wei Hsin (1)
Chin-Hao Chang (1)
Pan-Chyr Yang (7)
Chien-Jen Chen (8)
Chao A. Hsiung (1) - 关键词：Lung cancer ; Environmental tobacco smoke ; Never smokers ; Case–control study ; Risk factors
- 刊名：Cancer Causes and Control
- 出版年：2013
- 出版时间：March 2013
- 年：2013
- 卷：24
- 期：3
- 页码：567-576
- 全文大小：208KB
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Chin-Fu Hsiao (1)
Gee-Chen Chang (2)
Ying-Huang Tsai (3)
Ming-Shyan Huang (4)
Wu-Chou Su (5)
Yuh-Min Chen (6)
Che-Wei Hsin (1)
Chin-Hao Chang (1)
Pan-Chyr Yang (7)
Chien-Jen Chen (8)
Chao A. Hsiung (1)
1. Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 350, Taiwan
2. Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
3. Department of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taipei, Taiwan
4. Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
5. Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan
6. Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan
7. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
8. Genomics Research Center, Academia Sinica, Taipei, Taiwan - ISSN：1573-7225
文摘
Objective Lung cancers that occur in never smokers differ from those that occur in smokers. We performed an analysis of potential epidemiological risk factors for lung cancer among never smokers. Methods In this hospital-based matched case–control study, all 1,540 matched case–control pairs were Han Chinese in Taiwan. The data on demographic characteristics, smoking habit, exposure to environmental tobacco smoke, medical history of lung diseases, family history of lung cancer, and female characteristics were collected from a structured questionnaire. A multiple conditional logistic regression was used to estimate odds ratios and 95?% confidence intervals after adjusting for possible confounders. Results Overall, several epidemiological factors of lung cancer in never smokers were different between males and females. For the female population, subjects who were exposed to environmental tobacco smoke (OR?=?1.39, 95?% CI?=?1.17-.67) with a history of pulmonary tuberculosis and with family history of lung cancer in first-degree relatives (OR?=?2.44, 95?% CI?=?1.79-.32) had higher risk of lung cancer, while subjects with a history of hormone replacement therapy and using fume extractors for those who cooked were protective. For the male population, only subjects with family history of lung cancer in first-degree relatives (OR?=?2.77, 95?% CI?=?1.53-.01) were significantly associated with risk of lung cancer. Conclusion This study provides insights about the epidemiological factors of lung cancer in never smokers, adding to existing evidence that family history of lung cancer and environmental tobacco smoke may moderate lung cancer risk.