Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain

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• 作者：Hugo F Miranda (1) (2)
  Viviana Noriega (2) (3)
  Pilar Zanetta (1)
  Juan Carlos Prieto (1) (3)
  Juan Carlos Prieto-Rayo (1)
  Nicol谩s Aranda (1)
  Fernando Sierralta (1) (4)
  
  1. Pharmacology Program ; ICBM ; Faculty of Medicine ; Universidad de Chile ; Independencia 1027 ; Santiago ; Chile
  2. Faculty of Medicine ; School of Pharmacy ; Universidad Andr茅s Bello ; Av. Rep煤blica 252 ; Santiago ; Chile
  3. Cardiovascular Department ; Hospital Cl铆nico ; Universidad de Chile ; Santos Dumont 999 ; Santiago ; Chile
  4. Faculty of Odontology ; Universidad Finis Terrae ; Providencia 1509 ; Santiago ; Chile
  
• 关键词：Interaction opioid ; opioid ; Acetic acid writhing test ; Hot plate assay ; Isobolographic analysis ; Synergism
• 刊名：Journal of Biomedical Science
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：21
• 期：1
• 全文大小：606 KB
• 参考文献：1. Trescot, AM, Datta, S, Lee, M, Hanssen, H (2008) Opioid pharmacology. Pain Pysician 11: pp. S133-S153
  2. Waldhoer, M, Barlett, SE, Whistler, JL (2004) Opioid receptors. Ann Rev Biochem 73: pp. 753-990 f="http://dx.doi.org/10.1146/annurev.biochem.73.011303.073940" target="_blank" title="It opens in new window">CrossRef
  3. Mao, J, Gols, MS, Backonja, MM (2011) Combination drug therapy for chronic pain: a call for more clinical studies. J Pain 12: pp. 157-166 f="http://dx.doi.org/10.1016/j.jpain.2010.07.006" target="_blank" title="It opens in new window">CrossRef
  4. Lashbrook, JM, Ossipov, MH, Hunter, JC, Raffa, RB, Tallarida, RJ, Porreca, F (1999) Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. Pain 82: pp. 65-72 f="http://dx.doi.org/10.1016/S0304-3959(99)00031-7" target="_blank" title="It opens in new window">CrossRef
  5. Miranda, HF, Puig, MM, Prieto, JC, Pinardi, G (2006) Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. Pain 121: pp. 22-28 f="http://dx.doi.org/10.1016/j.pain.2005.11.012" target="_blank" title="It opens in new window">CrossRef
  6. Miranda, HF, Puig, MM, Romero, MA, Prieto, JC (2009) Effect of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice. Fund Clin Pharmacol 23: pp. 81-88 f="http://dx.doi.org/10.1111/j.1472-8206.2008.00636.x" target="_blank" title="It opens in new window">CrossRef
  7. Silva-Moreno, A, Gonzalez-Espinosa, CM, Cruz, SL (2012) Synergistic antinociceptive actions and tolerance development produced by morphine-fentanyl coadministration: correlation with 渭-opioid receptor internalization. Eur J Pharmacol 674: pp. 239-247 f="http://dx.doi.org/10.1016/j.ejphar.2011.10.034" target="_blank" title="It opens in new window">CrossRef
  8. Ramiro, S, Radner, H, Heijde, DM, Buchbinder, R, Aletaha, D, Landew茅, RB (2012) Combination therapy for pain management in inflammatory arthritis: a Cochrane systematic review. J Rheumatol 90: pp. 47-55
  9. Kolesnikov, YA, Oksman, G, Pasternak, GW (2010) Topical methadone and meperidine analgesic synergy in the mouse. Eur J Pharmacol 38: pp. 61-64 f="http://dx.doi.org/10.1016/j.ejphar.2010.04.020" target="_blank" title="It opens in new window">CrossRef
  10. Miranda, HF, Noriega, V, Zepeda, RJ, Sierralta, F, Prieto, JC (2012) Synergism between fentanyl and tramadol in tonic inflammatory pain: the orofacial formalin test. Inflammation 35: pp. 1132-1137 f="http://dx.doi.org/10.1007/s10753-011-9420-7" target="_blank" title="It opens in new window">CrossRef
  11. Whittle, SL, Richards, BL, Husni, E, Buchbinder, R (2011) Opioid therapy for treating rheumatoid arthritis pain. Cochrane Database Syst Rev 釁? pp. CD003113
  12. Kurihara, T, Nonaka, T, Tanabe, T (2003) Acetic acid conditioning stimulus induced long-lasting antinociception of somatic inflammatory pain. Pharmacol Biochem Behav 74: pp. 841-849 f="http://dx.doi.org/10.1016/S0091-3057(03)00014-5" target="_blank" title="It opens in new window">CrossRef
  13. Pavao-de-Souza, G, Zarpelon, F, Tedeschi, AC, Mizokami, GC, Sanson, SS, Cunha, TM, Ferreira, SH, Cunha, FQ, Casagrande, R, Verri, WA (2012) Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI (3)K and microglia in mice. Pharmacol Biochem Behav 101: pp. 320-328 f="http://dx.doi.org/10.1016/j.pbb.2012.01.018" target="_blank" title="It opens in new window">CrossRef
  14. Bars, D, Gozariu, M, Cadden, SW (2001) Animal models of nociception. Pharmacol Rev 53: pp. 597-652
  15. Koster, R, Anderson, M, Beer, EJ (1959) Acetic acid for analgesic screening. Fed Proc 18: pp. 412-414
  16. Eddy, NB, Leimbach, D (1953) Synthetic analgesics: II dithienylbutenyl- and dithienylbutenylamines. J Pharmacol Exp Ther 107: pp. 385-393
  17. Tallarida, RJ (2000) Drug synergism and dose-effect data analysis. Chapman & Hall/CRC Press. USA, Boca Rat贸n f="http://dx.doi.org/10.1201/9781420036107" target="_blank" title="It opens in new window">CrossRef
  18. Takemori, AE, Ho, BY, Naeseth, JS, Portoghese, PS (1988) Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. J Pharmacol Exp Ther 246: pp. 255-258
  19. Suzuki, T, Narita, M, Takahashi, Y, Misawa, M, Nagase, H (1992) Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine. Eur J Pharmacol 213: pp. 91-97 f="http://dx.doi.org/10.1016/0014-2999(92)90237-X" target="_blank" title="It opens in new window">CrossRef
  20. Satyanarayana, PSV, Jain, NK, Singh, A, Kulkarni, SK (2004) Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice. Prog Neuropsychopharmacol Biol Psychiatr 28: pp. 641-649 f="http://dx.doi.org/10.1016/j.pnpbp.2004.01.015" target="_blank" title="It opens in new window">CrossRef
  21. Naidu, PS, Lichtman, AH, Archer, CC, May, EL, Harris, LS, Aceto, MD (2007) NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action. Eur J Pharmacol 566: pp. 132-136 f="http://dx.doi.org/10.1016/j.ejphar.2007.03.031" target="_blank" title="It opens in new window">CrossRef
  22. Mary, F, Divin, MF, Holden Ko, MC, Traynor, JR (2008) Comparison of the opioid receptor antagonist properties of naltrexone and 6尾-naltrexol in morphine-na茂ve and morphine-dependent mice. Eur J Pharmacol 583: pp. 48-55 f="http://dx.doi.org/10.1016/j.ejphar.2008.01.004" target="_blank" title="It opens in new window">CrossRef
  23. Loscalzo, LM, Wasowski, C, Paladini, AC, Marder, M (2008) Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur J Pharmacol 580: pp. 306-313 f="http://dx.doi.org/10.1016/j.ejphar.2007.11.011" target="_blank" title="It opens in new window">CrossRef
  24. Reichter, A, Daughters, RS, Rivard, R, Simone, DA (2001) Peripheral and preemptive opioid antinociception in a mouse visceral pain model. Pain 89: pp. 221-227 f="http://dx.doi.org/10.1016/S0304-3959(00)00365-1" target="_blank" title="It opens in new window">CrossRef
  25. Raynor, K, Kong, H, Chen, Y, Yasuda, Y, Bell, GI, Reisine, T (1994) Pharmacological characterization of cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol 45: pp. 330-334
  26. Raffa, RB, Friderichs, E, Reimann, W, Shank, RP, Codd, EE, Vaught, JL, Jacoby, HI, Selve, N (1993) Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exper Ther 267: pp. 331-340
  27. McQuay, HJ, Sullivan, AF, Smallman, K, Dickenson, H (1989) Intrathecal opioids, potency and lipophilicity. Pain 36: pp. 111-115 f="http://dx.doi.org/10.1016/0304-3959(89)90118-8" target="_blank" title="It opens in new window">CrossRef
  28. Miranda, HF, Silva, E, Pinardi, G (2004) Synergy between the antinociceptive effects of morphine and NSAIDs. Can J Physiol Pharmacol 82: pp. 331-338
  29. Romero, A, Miranda, HF, Puig, MM (2010) Antinociceptive effects of morphine, fentanyl, tramadol and their combination, in morphine-tolerant mice. Pharmacol Biochem Behav 97: pp. 363-369 f="http://dx.doi.org/10.1016/j.pbb.2010.09.005" target="_blank" title="It opens in new window">CrossRef
  30. Sirohi, S, Dighe, SV, Walker, EA, Yoburn, CB (2008) The analgesic efficacy of fentanyl: relation to tolerance and 渭-opioid receptor regulation. Pharmacol Biochem Behav 91: pp. 115-120 f="http://dx.doi.org/10.1016/j.pbb.2008.06.019" target="_blank" title="It opens in new window">CrossRef
  31. Collier, HOJ, Dinneen, LC, Johnson, CA, Schneider, C (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 32: pp. 295-310 f="http://dx.doi.org/10.1111/j.1476-5381.1968.tb00973.x" target="_blank" title="It opens in new window">CrossRef
  32. Neelakantan, H, Walker, EA (2012) Temperature-dependent enhancement of the antinociceptive effects of opioids in combination with gabapentin in mice. Eur J Pharmacol 686: pp. 55-59 f="http://dx.doi.org/10.1016/j.ejphar.2012.04.042" target="_blank" title="It opens in new window">CrossRef
  33. Lemberg, K, Kontinen, VS, Viljakka, K, Kyl芒nlathi, I, Yli-Kauhaluoma, J, Kalso, E (2006) Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. Anesth Anal 102: pp. 1768-1774 f="http://dx.doi.org/10.1213/01.ane.0000205751.88422.41" target="_blank" title="It opens in new window">CrossRef
  34. Pan, YX, Xu, J, Bolan, E, Moskowitz, HS, Xu, M, Pasternak, GW (2005) Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing. Mol Pharmacol 68: pp. 866-875
  35. Hojo, M, Sudo, Y, Ando, Y, Minami, K, Takada, M, Matsubara, T, Kanaide, M, Taniyama, K, Sumikawa, K, Uezono, Y (2008) Mu-Opioid receptor forms a functional heterodimer with cannabinoid CB1 receptor: electrophysiological and FRET assay analysis. J Pharmacol Sci 108: pp. 308-319
  36. Barrera, NP, Morales, B, Torres, S, Villal贸n, M (2005) Principles: mechanisms and modeling of synergism in cellular responses. Trends Pharmacol Sci 26: pp. 526-532 f="http://dx.doi.org/10.1016/j.tips.2005.08.003" target="_blank" title="It opens in new window">CrossRef
  37. Simmons, DL, Botting, RM, Timothy, HLA (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 56: pp. 387-437 f="http://dx.doi.org/10.1124/pr.56.3.3" target="_blank" title="It opens in new window">CrossRef
  38. Zhang, Z, Pan, ZZ (2010) Synaptic mechanism for functional synergism between 未- and 渭- opioid receptors. J Neurosci 30: pp. 4735-4745 f="http://dx.doi.org/10.1523/JNEUROSCI.5968-09.2010" target="_blank" title="It opens in new window">CrossRef
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  
• 出版者：Springer Netherlands
• ISSN：1423-0127

文摘

Background Opioids have been used for the management of pain and coadministration of two opioids may induce synergism. In a model of tonic pain, the acetic acid writhing test and in a phasic model, the hot plate, the antinociceptive interaction between fentanyl, methadone, morphine, and tramadol was evaluated. Results The potency of opioids in the writhing test compared to the hot plate assay was from 2.5 (fentanyl) to 15.5 (morphine) times, respectively. The ED50 was used in a fixed ratio for each of the six pairs of opioid combinations, which, resulted in a synergistic antinociception except for methadone/tramadol and fentanyl/tramadol which were additive, in the hot plate. The opioid antagonists naltrexone, naltrindole and nor-binaltorphimine, suggests that the synergism of morphine combinations are due to the activation of MOR subtypes with partially contribution of DOR and KOR, however fentanyl and methadone combinations are partially due to the activation of MOR and DOR subtypes and KOR lack of participation. The antinociceptive effects of tramadol combinations, are partially due to the activation of MOR, DOR and KOR opioid subtypes. Conclusion These results suggets that effectiveness and magnitude of the interactions between opioids are dependent on pain stimulus intensity.