Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis
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- 作者：Chong Zeng ; Rui Xing ; Jing Liu ; Feiyue Xing
- 关键词：CSL ; dependent Notch ; CSL ; independent Notch ; mTORC ; Apoptosis ; Cell
- 刊名：Apoptosis
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：21
- 期：1
- 页码：1-12
- 全文大小：910 KB
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Rui Xing (3)
Jing Liu (4)
Feiyue Xing (1) (2)
1. Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, 510632, China
2. Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University, Guangzhou, 510632, China
3. Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China
4. Department of Stomatology, Jinan University, Guangzhou, 510632, China - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Oncology
Cancer Research
Cell Biology
Biochemistry
Virology - 出版者：Springer Netherlands
- ISSN：1573-675X
文摘
Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with a series of signaling processes. Notch signaling is found evolutionarily conserved in many species, playing a critical role in embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus of this review is on currently novel advances about roles of CSL-dependent and independent Notch signaling pathways in cell apoptosis. The CSL can bind Notch intracellular domain (NIC) to act as a switch in mediating transcriptional activation or inactivation of the Notch signaling pathway downstream genes in the nucleus. It shows that CSL-dependent signaling regulates the cell apoptosis through Hes-1-PTEN-AKT-mTOR signaling, but rather the CSL-independent signaling mediates the cell apoptosis possibly via NIC-mTORC2-AKT-mTOR signaling, providing a new insight into apoptotic mechanisms. Keywords CSL-dependent Notch CSL-independent Notch mTORC Apoptosis Cell