miR-22 targets the 3-UTR of HMGB1 and inhibits the HMGB1-associated autophagy in osteosarcoma cells during chemotherapy

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• 作者：Xuefeng Li (1)
  Sijia Wang (2)
  Yan Chen (3)
  Guifeng Liu (4)
  Xiaoyu Yang (5)
  
• 关键词：miR ; 22 ; HMGB1 ; Autophagy ; Osteosarcoma cells ; Chemotherapy
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：35
• 期：6
• 页码：6021-6028
• 全文大小：
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• 作者单位：Xuefeng Li (1)
  Sijia Wang (2)
  Yan Chen (3)
  Guifeng Liu (4)
  Xiaoyu Yang (5)
  
  1. Department of Anesthesiology, China-Japan Union Hospital, Jilin University, Changchun, China
  2. China-Japan Union Hospital, Jilin University, Changchun, China
  3. Department of Endocrinology, Second Hospital, Jilin University, Changchun, China
  4. Department of Radiology, China-Japan Union Hospital, Jilin University, No. 126 of Xiantai street, Erdao District, 130033, Changchun, China
  5. Department of Orthopedics, China-Japan Union Hospital, Jilin University, No. 126 of Xiantai street, Erdao District, 130033, Changchun, China
  
• ISSN：1423-0380

文摘

Osteosarcoma is the most common malignant bone tumor for children and adolescents, and the frequent acquisition of drug-resistant phenotypes and the occurrence of “secondary malignancies-are often associated with chemotherapy and are significant obstacles to achieving favorable outcomes. Thus, it is urgent to identify the molecular mechanisms underlying the chemoresistance of osteosarcoma. In this study, we showed that miR-22 and high-mobility group box 1 (HMGB1) were deregulated in osteosarcoma cells, post-chemotherapy; the upregulated HMGB1 mediated autophagy and contributed to chemotherapy resistance in osteosarcoma in vitro. However, possibly as a compensatory effect, miR-22 was also upregulated during the chemotherapy, and the overexpressed miR-22 targeted the 3-UTR of HMGB1 and inhibits the HMGB1-promoted autophagy. Our study suggests a complexity in the regulation of autophagy by miR-22 and HMGB1 during chemotherapy resistance in osteosarcoma. These results reveal novel potential role of miR-22 against chemotherapy resistance during the treatment of osteosarcoma.