The α/β ratio dose-range independent: application of the generalized linear-quadratic (gLQ) model

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• 作者：Cancan Zhang ; Nina A. Mayr ; Simon S. Lo ; Lanchun Lu…
• 关键词：Radiation therapy ; Generalized linear ; quadratic model ; In vitro cell lines
• 刊名：Journal of Radiation Oncology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：4
• 期：3
• 页码：309-314
• 全文大小：781 KB
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• 作者单位：Cancan Zhang (1)
  Nina A. Mayr (2)
  Simon S. Lo (3)
  Lanchun Lu (1)
  Kaile Li (1)
  Yi Zheng (4)
  William T. C. Yuh (5)
  Zhibin Huang (6)
  
  1. Department of Radiation Oncology, The Ohio State University, Columbus, OH, 43210, USA
  2. Department of Radiation Oncology, University of Washington, Seattle, WA, 98195, USA
  3. Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA
  4. Radiation Oncology, JFK Comprehensive Cancer Institute, Lake Worth, FL, 33461, USA
  5. Department of Radiology, University of Washington, Seattle, WA, 98195, USA
  6. Department of Radiation Oncology and Department of Physics, East Carolina University, 600 Moye Blvd, Greenville, NC, 27834, USA
  
• 刊物主题：Oncology; Imaging / Radiology; Cancer Research; Surgical Oncology; Surgery; Radiotherapy;
• 出版者：Springer Berlin Heidelberg
• ISSN：1948-7908

文摘

Objective The dose-range dependence of α/β ratio of the linear-quadratic (LQ) model for ?0 Gy single doses has recently been reported. We previously proposed a generalized LQ (gLQ) model to address the LQ model limitations in large-dose regions. Here, we apply the gLQ model to large-dose-range in vitro irradiation data to investigate the dose-range dependence of the α/β ratio.