The hierarchy quorum sensing network in Pseudomonas aeruginosa
详细信息 查看全文
- 作者：Jasmine Lee (1)
Lianhui Zhang (1) (2)
1. Institute of Molecular and Cell Biology ; Agency for Science ; Technology and Research ; Singapore ; Singapore
2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control ; College of Natural Resources and Environmental Sciences ; South China Agricultural University ; Guangzhou ; 510642 ; China - 关键词：quorum sensing ; IQS ; PQS ; las ; rhl ; Pseudomonas aeruginosa ; virulence ; environmental factors
- 刊名：Protein & Cell
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：6
- 期：1
- 页码：26-41
- 全文大小：631 KB
- 参考文献：1. Abe A, Matsuzawa T, Kuwae A (2005) Type-III effectors: sophisticated bacterial virulence factors. C R Biol 328:413鈥?28
2. Adam EC, Mitchell BS, Schumacher DU, Grant G, Schumacher U (1997) / Pseudomonas aeruginosa II lectin stops human ciliary beating: therapeutic implications of fucose. Am J Respir Crit Care Med 155:2102鈥?104
3. Albus AM, Pesci EC, Runyen-Janecky LJ, West SE, Iglewski BH (1997) Vfr controls quorum sensing in / Pseudomonas aeruginosa. J Bacteriol 179:3928鈥?935
4. Anba J, Bidaud M, Vasil ML, Lazdunski A (1990) Nucleotide sequence of the / Pseudomonas aeruginosa phoB gene, the regulatory gene for the phosphate regulon. J Bacteriol 172:4685鈥?689
5. Bains M, Fernandez L, Hancock RE (2012) Phosphate starvation promotes swarming motility and cytotoxicity of / Pseudomonas aeruginosa. Appl Environ Microbiol 78:6762鈥?768
6. Baysse C, Cullinane M, D茅nervaud V, Burrowes E, Dow JM, Morrissey JP, Tam L, Trevors JT, O鈥橤ara F (2005) Modulation of quorum sensing in / Pseudomonas aeruginosa through alteration of membrane properties. Microbiology 151:2529鈥?542
7. Bertani I, Venturi V (2004) Regulation of the / N-acyl homoserine lactone-dependent quorum-sensing system in rhizosphere / Pseudomonas putida WCS358 and cross-talk with the stationary-phase RpoS sigma factor and the global regulator GacA. Appl Environ Microbiol 70:5493鈥?502
8. Blier A-S, Veron W, Bazire A, Gerault E, Taupin L, Vieillard J, Rehel K, Dufour A, Le Derf F, Orange N (2011) C-type natriuretic peptide modulates quorum sensing molecule and toxin production in / Pseudomonas aeruginosa. Microbiology 157:1929鈥?944
9. Bonomo RA, Szabo D (2006) Mechanisms of multidrug resistance in / Acinetobacter species and / Pseudomonas aeruginosa. Clinical Infectious Diseases 43(Suppl 2):S49鈥揝56
10. Borlee BR, Geske GD, Blackwell HE, Handelsman J (2010) Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in / Pseudomonas aeruginosa by high-throughput screening. Appl Environ Microbiol 76:8255鈥?258
11. Branny P, Pearson JP, Pesci EC, Kohler T, Iglewski BH, Van Delden C (2001) Inhibition of quorum sensing by a / Pseudomonas aeruginosa dksA homologue. J Bacteriol 183:1531鈥?539
12. Brint JM, Ohman DE (1995) Synthesis of multiple exoproducts in / Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. Journal of Bacteriology 177:7155鈥?163
13. Cabrol S, Olliver A, Pier GB, Andremont A, Ruimy R (2003) Transcription of quorum-sensing system genes in clinical and environmental isolates of / Pseudomonas aeruginosa. J Bacteriol 185:7222鈥?230
14. Camilli A, Bassler BL (2006) Bacterial small-molecule signaling pathways. Science 311:1113鈥?116
15. Campodonico VL, Gadjeva M, Paradis-Bleau C, Uluer A, Pier GB (2008) Airway epithelial control of / Pseudomonas aeruginosa infection in cystic fibrosis. Trends Mol Med 14:120鈥?33
16. Cao JG, Meighen EA (1993) Biosynthesis and stereochemistry of the autoinducer controlling luminescence in / Vibrio harveyi. J Bacteriol 175:3856鈥?862
17. Cao H, Krishnan G, Goumnerov B, Tsongalis J, Tompkins R, Rahme LG (2001) A quorum sensing-associated virulence gene of / Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proc Natl Acad Sci USA 98:14613鈥?4618
18. Castric PA (1983) Hydrogen cyanide production by / Pseudomonas aeruginosa at reduced oxygen levels. Can J Microbiol 29:1344鈥?349
19. Castric P (1994) Influence of oxygen on the / Pseudomonas aeruginosa hydrogen cyanide synthase. Curr Microbiol 29:19鈥?1
20. Castric PA, Ebert RF, Castric KF (1979) The relationship between growth phase and cyanogenesis in / Pseudomonas aeruginosa. Curr Microbiol 2:287鈥?92
21. Chernish RN, Aaron SD (2003) Approach to resistant gram-negative bacterial pulmonary infections in patients with cystic fibrosis. Curr Opin Pulm Med 9:509鈥?15
22. Chugani S, Greenberg E (2007) The influence of human respiratory epithelia on / Pseudomonas aeruginosa gene expression. Microbial pathogenesis 42:29鈥?5
23. Chugani SA, Whiteley M, Lee KM, D鈥橝rgenio D, Manoil C, Greenberg EP (2001) QscR, a modulator of quorum-sensing signal synthesis and virulence in / Pseudomonas aeruginosa. Proc Natl Acad Sci USA 98:2752鈥?757
24. Ciofu O, Mandsberg LF, Bjarnsholt T, Wassermann T, H酶iby N (2010) Genetic adaptation of / Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in / mucA and/or / lasR mutants. Microbiology 156:1108鈥?119
25. Coleman JP, Hudson LL, McKnight SL, Farrow JM, Calfee MW, Lindsey CA, Pesci EC (2008) / Pseudomonas aeruginosa PqsA is an anthranilate-coenzyme A ligase. J Bacteriol 190:1247鈥?255
26. Collier DN, Anderson L, McKnight SL, Noah TL, Knowles M, Boucher R, Schwab U, Gilligan P, Pesci EC (2002) A bacterial cell to cell signal in the lungs of cystic fibrosis patients. FEMS Microbiol Lett 215:41鈥?6
27. Cook JMI, Harragan B (1992) In: Proceedings of the 92nd annual meeting of the american society for microbiology. Paper presented at 92nd annual meeting of the american society for microbiology, New Orleans
28. Cornforth JW, James AT (1956) Structure of a naturally occurring antagonist of dihydrostreptomycin. The Biochemical Journal 63:124鈥?30
29. Cornforth DM, Popat R, McNally L, Gurney J, Scott-Phillips TC, Ivens A, Diggle SP, Brown SP (2014) Combinatorial quorum sensing allows bacteria to resolve their social and physical environment. Proc Natl Acad Sci 3(4):220鈥?27
30. Costerton JW (2001) Cystic fibrosis pathogenesis and the role of biofilms in persistent infection. Trends Microbiol 9:50鈥?2
31. Daddaoua A, Fillet S, Fern谩ndez M, Udaondo Z, Krell T, Ramos JL (2012) Genes for carbon metabolism and the ToxA virulence factor in / Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS. PLoS One 7:e39390
32. D鈥橝rgenio DA, Calfee MW, Rainey PB, Pesci EC (2002) Autolysis and autoaggregation in / Pseudomonas aeruginosa colony morphology mutants. J Bacteriol 184:6481鈥?489
33. D鈥橝rgenio DA, Wu M, Hoffman LR, Kulasekara HD, Deziel E, Smith EE, Nguyen H, Ernst RK, Larson Freeman TJ, Spencer DH et al (2007) Growth phenotypes of / Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol 64:512鈥?33
34. de Kievit T, Seed PC, Nezezon J, Passador L, Iglewski BH (1999) RsaL, a novel repressor of virulence gene expression in / Pseudomonas aeruginosa. J Bacteriol 181:2175鈥?184
35. Dekimpe V, Deziel E (2009) Revisiting the quorum-sensing hierarchy in / Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors. Microbiology 155:712鈥?23
36. Denervaud V, TuQuoc P, Blanc D, Favre-Bonte S, Krishnapillai V, Reimmann C, Haas D, van Delden C (2004) Characterization of cell-to-cell signaling-deficient / Pseudomonas aeruginosa strains colonizing intubated patients. J Clin Microbiol 42:554鈥?62
37. Deng Y, Wu J, Tao F, Zhang LH (2011) Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria. Chem Rev 111:160鈥?73
38. Denning GM, Wollenweber LA, Railsback MA, Cox CD, Stoll LL, Britigan BE (1998) / Pseudomonas pyocyanin increases interleukin-8 expression by human airway epithelial cells. Infect Immun 66:5777鈥?784
39. Deziel E, Lepine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG (2004) Analysis of / Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci USA 101:1339鈥?344
40. D茅ziel E, Gopalan S, Tampakaki AP, L茅pine F, Padfield KE, Saucier M, Xiao G, Rahme LG (2005) The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of / N-acyl-l-homoserine lactones. Mol Microbiol 55:998鈥?014
41. Diggle SP, Winzer K, Lazdunski A, Williams P, Camara M (2002) Advancing the quorum in / Pseudomonas aeruginosa: MvaT and the regulation of / N-acylhomoserine lactone production and virulence gene expression. J Bacteriol 184:2576鈥?586
42. Diggle SP, Winzer K, Chhabra SR, Worrall KE, C谩mara M, Williams P (2003) The / Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol Microbiol 50:29鈥?3
43. Diggle SP, Matthijs S, Wright VJ, Fletcher MP, Chhabra SR, Lamont IL, Kong X, Hider RC, Cornelis P, C谩mara M (2007) The / Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem Biol 14:87鈥?6
44. Doshi HK, Chua K, Kagda F, Tambyah PA (2011) Multi drug resistant pseudomonas infection in open fractures post definitive fixation leading to limb loss: a report of three cases. International Journal of Case Reports and Images (IJCRI) 2:1鈥?
45. Dubern JF, Diggle SP (2008) Quorum sensing by 2-alkyl-4-quinolones in / Pseudomonas aeruginosa and other bacterial species. Mol Biosyst 4:882鈥?88
46. Eberhard A (1972) Inhibition and activation of bacterial luciferase synthesis. J Bacteriol 109:1101鈥?105
47. Eberhard A, Burlingame AL, Eberhard C, Kenyon GL, Nealson KH, Oppenheimer NJ (1981) Structural identification of autoinducer of / Photobacterium fischeri luciferase. Biochemistry 20:2444鈥?449
48. Farrow JM 3rd, Sund ZM, Ellison ML, Wade DS, Coleman JP, Pesci EC (2008) PqsE functions independently of PqsR- / Pseudomonas quinolone signal and enhances the rhl quorum-sensing system. J Bacteriol 190:7043鈥?051
49. Filloux A, Bally M, Soscia C, Murgier M, Lazdunski A (1988) Phosphate regulation in / Pseudomonas aeruginosa: cloning of the alkaline phosphatase gene and identification of / phoB-and / phoR-like genes. Mol Gen Genet 212:510鈥?13
50. Frisk A, Schurr JR, Wang G, Bertucci DC, Marrero L, Hwang SH, Hassett DJ, Schurr MJ (2004) Transcriptome analysis of / Pseudomonas aeruginosa after interaction with human airway epithelial cells. Infect Immun 72:5433鈥?438
51. Fuqua C (2006) The QscR quorum-sensing regulon of / Pseudomonas aeruginosa: an orphan claims its identity. J Bacteriol 188:3169鈥?171
52. Fuqua WC, Winans SC, Greenberg EP (1994) Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol 176:269鈥?75
53. Gallagher LA, McKnight SL, Kuznetsova MS, Pesci EC, Manoil C (2002) Functions required for extracellular quinolone signaling by / Pseudomonas aeruginosa. J Bacteriol 184:6472鈥?480
54. Gambello MJ, Iglewski BH (1991) Cloning and characterization of the / Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol 173:3000鈥?009
55. Gambello MJ, Kaye S, Iglewski BH (1993) LasR of / Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene ( / apr) and an enhancer of exotoxin A expression. Infect Immun 61:1180鈥?184
56. Gentry DR, Cashel M (1996) Mutational analysis of the / Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation. Mol Microbiol 19:1373鈥?384
57. Haddad A, Jensen V, Becker T, Haussler S (2009) The Pho regulon influences biofilm formation and type three secretion in / Pseudomonas aeruginosa. Environ Microbiol Rep 1:488鈥?94
58. Hamood AN, Griswold J, Colmer J (1996) Characterization of elastase-deficient clinical isolates of / Pseudomonas aeruginosa. Infect Immun 64:3154鈥?160
59. Hauser AR, Cobb E, Bod铆 M, Mariscal D, Vall茅s J, Engel JN, Rello J (2002) Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by / Pseudomonas aeruginosa. Crit Care Med 30:521鈥?28
60. Henry RL, Mellis CM, Petrovic L (1992) Mucoid / Pseudomonas aeruginosa is a marker of poor survival in cystic fibrosis. Pediatr Pulmonol 12:158鈥?61
61. Hense BA, Kuttler C, Muller J, Rothballer M, Hartmann A, Kreft JU (2007) Does efficiency sensing unify diffusion and quorum sensing? Nature Rev Microbiol 5:230鈥?39
62. Heurlier K, D茅nervaud V, Pessi G, Reimmann C, Haas D (2003) Negative control of quorum sensing by RpoN (蟽54) in / Pseudomonas aeruginosa PAO1. J Bacteriol 185:2227鈥?235
63. Hoffman LR, Kulasekara HD, Emerson J, Houston LS, Burns JL, Ramsey BW, Miller SI (2009) / Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression. J Cyst Fibros 8:66鈥?0
64. Hsieh Y-J, Wanner BL (2010) Global regulation by the seven-component Pi signaling system. Curr Opin Microbiol 13:198鈥?03
65. Huang JJ, Petersen A, Whiteley M, Leadbetter JR (2006) Identification of QuiP, the product of gene PA1032, as the second acyl-homoserine lactone acylase of / Pseudomonas aeruginosa PAO1. Appl Environ Microbiol 72:1190鈥?197
66. Hueck CJ (1998) Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev 62:379鈥?33
67. Jackowski JT, Szepfalusi Z, Wanner DA, Seybold Z, Sielczak MW, Lauredo IT, Adams T, Abraham WM, Wanner A (1991) Effects of / P. aeruginosa-derived bacterial products on tracheal ciliary function: role of O2 radicals. Am J Physiol 260:L61鈥揕67
68. Jackson AA, Gross MJ, Daniels EF, Hampton TH, Hammond JH, Vallet-Gely I, Dove SL, Stanton BA, Hogan DA (2013) Anr and its activation by PlcH activity in / Pseudomonas aeruginosa host colonization and virulence. J Bacteriol 195:3093鈥?104
69. Jensen V, L枚ns D, Zaoui C, Bredenbruch F, Meissner A, Dieterich G, M眉nch R, H盲ussler S (2006) RhlR expression in / Pseudomonas aeruginosa is modulated by the / Pseudomonas quinolone signal via PhoB-dependent and-independent pathways. J Bacteriol 188:8601鈥?606
70. Jones S, Yu B, Bainton NJ, Birdsall M, Bycroft BW, Chhabra SR, Cox AJ, Golby P, Reeves PJ, Stephens S et al (1993) The lux autoinducer regulates the production of exoenzyme virulence determinants in / Erwinia carotovora and / Pseudomonas aeruginosa. EMBO J 12:2477鈥?482
71. Joseleau-Petit D, Vinella D, D鈥橝ri R (1999) Metabolic alarms and cell division in / Escherichia coli. J Bacteriol 181:9鈥?4
72. Jude F, Kohler T, Branny P, Perron K, Mayer MP, Comte R, van Delden C (2003) Posttranscriptional control of quorum-sensing-dependent virulence genes by DksA in / Pseudomonas aeruginosa. J Bacteriol 185:3558鈥?566
73. Juhas M, Wiehlmann L, Huber B, Jordan D, Lauber J, Salunkhe P, Limpert AS, von Gotz F, Steinmetz I, Eberl L et al (2004) Global regulation of quorum sensing and virulence by VqsR in / Pseudomonas aeruginosa. Microbiology 150:831鈥?41
74. Kessler E, Safrin M, Olson JC, Ohman DE (1993) Secreted LasA of / Pseudomonas aeruginosa is a staphylolytic protease. J Biol Chem 268:7503鈥?508
75. Kim EJ, Sabra W, Zeng AP (2003) Iron deficiency leads to inhibition of oxygen transfer and enhanced formation of virulence factors in cultures of / Pseudomonas aeruginosa PAO1. Microbiology 149:2627鈥?634
76. Kiratisin P, Tucker KD, Passador L (2002) LasR, a transcriptional activator of / Pseudomonas aeruginosa virulence genes, functions as a multimer. J Bacteriol 184:4912鈥?919
77. Konings AF, Martin LW, Sharples KJ, Roddam LF, Latham R, Reid DW, Lamont IL (2013) / Pseudomonas aeruginosa uses multiple pathways to acquire iron during chronic infection in cystic fibrosis lungs. Infect Immun 81:2697鈥?704
78. Kosorok MR, Zeng L, West SE, Rock MJ, Splaingard ML, Laxova A, Green CG, Collins J, Farrell PM (2001) Acceleration of lung disease in children with cystic fibrosis after / Pseudomonas aeruginosa acquisition. Pediatr Pulmonol 32:277鈥?87
79. Krieg DP, Helmke RJ, German VF, Mangos JA (1988) Resistance of mucoid / Pseudomonas aeruginosa to nonopsonic phagocytosis by alveolar macrophages in vitro. Infect Immun 56:3173鈥?179
80. Laarman AJ, Bardoel BW, Ruyken M, Fernie J, Milder FJ, van Strijp JA, Rooijakkers SH (2012) / Pseudomonas aeruginosa alkaline protease blocks complement activation via the classical and lectin pathways. J Immunol 188:386鈥?93
81. Latifi A, Winson MK, Foglino M, Bycroft BW, Stewart GS, Lazdunski A, Williams P (1995) Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in / Pseudomonas aeruginosa PAO1. Mol Microbiol 17:333鈥?43
82. Latifi A, Foglino M, Tanaka K, Williams P, Lazdunski A (1996) A hierarchical quorum-sensing cascade in / Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Mol Microbiol 21:1137鈥?146
83. Lau GW, Ran H, Kong F, Hassett DJ, Mavrodi D (2004) / Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice. Infect Immun 72:4275鈥?278
84. Ledgham F, Soscia C, Chakrabarty A, Lazdunski A, Foglino M (2003a) Global regulation in / Pseudomonas aeruginosa: the regulatory protein AlgR2 (AlgQ) acts as a modulator of quorum sensing. Res Microbiol 154:207鈥?13
85. Ledgham F, Ventre I, Soscia C, Foglino M, Sturgis JN, Lazdunski A (2003b) Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of / Pseudomonas aeruginosa LasR and RhlR. Mol Microbiol 48:199鈥?10
86. Lee J, Wu J, Deng Y, Wang J, Wang C, Wang J, Chang C, Dong Y, Williams P, Zhang LH (2013) A cell-cell communication signal integrates quorum sensing and stress response. Nature Chem Biol 9:339鈥?43
87. L茅pine F, Milot S, D茅ziel E, He J, Rahme LG (2004) Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by / Pseudomonas aeruginosa. J Am Soc Mass Spectrom 15:862鈥?69
88. Lequette Y, Greenberg EP (2005) Timing and localization of rhamnolipid synthesis gene expression in / Pseudomonas aeruginosa biofilms. J Bacteriol 187:37鈥?4
89. Li LL, Malone JE, Iglewski BH (2007) Regulation of the / Pseudomonas aeruginosa quorum-sensing regulator VqsR. J Bacteriol 189:4367鈥?374
90. Lightbown JW, Jackson FL (1956) Inhibition of cytochrome systems of heart muscle and certain bacteria by the antagonists of dihydrostreptomycin: 2-alkyl-4-hydroxyquinoline N-oxides. Biochem J 63:130鈥?37
91. Mattmann ME, Blackwell HE (2010) Small molecules that modulate quorum sensing and control virulence in / Pseudomonas aeruginosa. J Org Chem 75:6737鈥?746
92. McEwan DL, Kirienko NV, Ausubel FM (2012) Host translational inhibition by / Pseudomonas aeruginosa exotoxin A triggers an immune response in / Caenorhabditis elegans. Cell Host Microbe 11:364鈥?74
93. McKnight SL, Iglewski BH, Pesci EC (2000) The / Pseudomonas quinolone signal regulates / rhl quorum sensing in / Pseudomonas aeruginosa. J Bacteriol 182:2702鈥?708
94. Nealson KH, Platt T, Hastings JW (1970) Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol 104:313鈥?22
95. Ng WL, Bassler BL (2009) Bacterial quorum-sensing network architectures. Annu Rev Genet 43:197鈥?22
96. Ochsner UA, Reiser J (1995) Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in / Pseudomonas aeruginosa. Proc Natl Acad Sci USA 92:6424鈥?428
97. Ochsner UA, Wilderman PJ, Vasil AI, Vasil ML (2002) GeneChip庐 expression analysis of the iron starvation response in / Pseudomonas aeruginosa: identification of novel pyoverdine biosynthesis genes. Mol Microbiol 45:1277鈥?287
98. Oglesby AG, Farrow JM, Lee J-H, Tomaras AP, Greenberg E, Pesci EC, Vasil ML (2008) The influence of iron on / Pseudomonas aeruginosa Physiology: a regulatory link between iron and quorum sensing. J Biol Chem 283:15558鈥?5567
99. Park PW, Pier GB, Preston MJ, Goldberger O, Fitzgerald ML, Bernfield M (2000) Syndecan-1 shedding is enhanced by LasA, a secreted virulence factor of / Pseudomonas aeruginosa. J Biol Chem 275:3057鈥?064
100. Parkins MD, Ceri H, Storey DG (2001) / Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Mol Microbiol 40:1215鈥?226
101. Passador L, Cook JM, Gambello MJ, Rust L, Iglewski BH (1993) Expression of / Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 260:1127鈥?130
102. Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP (1994) Structure of the autoinducer required for expression of / Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci USA 91:197鈥?01
103. Pearson JP, Passador L, Iglewski BH, Greenberg EP (1995) A second N-acylhomoserine lactone signal produced by / Pseudomonas aeruginosa. Proc Natl Acad Sci USA 92:1490鈥?494
104. Pereira CS, Thompson JA, Xavier KB (2013) AI-2-mediated signalling in bacteria. FEMS Microbiol Rev 37:156鈥?81
105. Pesci EC, Pearson JP, Seed PC, Iglewski BH (1997) Regulation of las and rhl quorum sensing in / Pseudomonas aeruginosa. J Bacteriol 179:3127鈥?132
106. Pesci EC, Milbank JB, Pearson JP, McKnight S, Kende AS, Greenberg EP, Iglewski BH (1999) Quinolone signaling in the cell-to-cell communication system of / Pseudomonas aeruginosa. Proc Natl Acad Sci USA 96:11229鈥?1234
107. Pessi G, Haas D (2000) Transcriptional control of the hydrogen cyanide biosynthetic genes / hcnABC by the anaerobic regulator ANR and the quorum-sensing regulators LasR and RhlR in / Pseudomonas aeruginosa. J Bacteriol 182:6940鈥?949
108. Pessi G, Williams F, Hindle Z, Heurlier K, Holden MT, C谩mara M, Haas D, Williams P (2001) The global posttranscriptional regulator RsmA modulates production of virulence determinants and / N-acylhomoserine lactones in / Pseudomonas aeruginosa. J Bacteriol 183:6676鈥?683
109. Rabin HR, Butler SM, Wohl MEB, Geller DE, Colin AA, Schidlow DV, Johnson CA, Konstan MW, Regelmann WE (2004) Pulmonary exacerbations in cystic fibrosis. Pediatr Pulmonol 37:400鈥?06
110. Rahme LG, Tan M-W, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM (1997) Use of model plant hosts to identify / Pseudomonas aeruginosa virulence factors. Proc Natl Acad Sci USA 94:13245鈥?3250
111. Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J et al (2000) Plants and animals share functionally common bacterial virulence factors. Proc Natl Acad Sci USA 97:8815鈥?821
112. Rampioni G, Schuster M, Greenberg EP, Bertani I, Grasso M, Venturi V, Zennaro E, Leoni L (2007) RsaL provides quorum sensing homeostasis and functions as a global regulator of gene expression in / Pseudomonas aeruginosa. Mol Microbiol 66:1557鈥?565
113. Redfield RJ (2002) Is quorum sensing a side effect of diffusion sensing? Trends Microbiol 10:365鈥?70
114. Reimmann C, Beyeler M, Latifi A, Winteler H, Foglino M, Lazdunski A, Haas D (1997) The global activator GacA of / Pseudomonas aeruginosa PAO positively controls the production of the autoinducer / N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase. Mol Microbiol 24:309鈥?19
115. Roy-Burman A, Savel RH, Racine S, Swanson BL, Revadigar NS, Fujimoto J, Sawa T, Frank DW, Wiener-Kronish JP (2001) Type III protein secretion is associated with death in lower respiratory and systemic / Pseudomonas aeruginosa infections. J Infect Dis 183:1767鈥?774
116. Ryall B, Davies JC, Wilson R, Shoemark A, Williams HD (2008) / Pseudomonas aeruginosa, cyanide accumulation and lung function in CF and non-CF bronchiectasis patients. Eur Respir J 32:740鈥?47
117. Sauer K, Cullen MC, Rickard AH, Zeef LA, Davies DG, Gilbert P (2004) Characterization of nutrient-induced dispersion in / Pseudomonas aeruginosa PAO1 biofilm. J Bacteriol 186:7312鈥?326
118. Schaber JA, Carty NL, McDonald NA, Graham ED, Cheluvappa R, Griswold JA, Hamood AN (2004) Analysis of quorum sensing-deficient clinical isolates of / Pseudomonas aeruginosa. J Med Microbiol 53:841鈥?53
119. Schafhauser J, Lepine F, McKay G, Ahlgren HG, Khakimova M, Nguyen D (2014) The stringent response modulates 4-hydroxy-2-alkylquinoline biosynthesis and quorum-sensing hierarchy in / Pseudomonas aeruginosa. J Bacteriol 196:1641鈥?650
120. Schertzer JW, Boulette ML, Whiteley M (2009) More than a signal: non-signaling properties of quorum sensing molecules. Trends Microbiol 17:189鈥?95
121. Schuster M, Greenberg EP (2006) A network of networks: quorum-sensing gene regulation in / Pseudomonas aeruginosa. Int J Med Microbiol 296:73鈥?1
122. Schuster M, Greenberg EP (2007) Early activation of quorum sensing in / Pseudomonas aeruginosa reveals the architecture of a complex regulon. BMC Genomics 8:287
123. Schuster M, Lostroh CP, Ogi T, Greenberg EP (2003) Identification, timing, and signal specificity of / Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J Bacteriol 185:2066鈥?079
124. Schuster M, Urbanowski ML, Greenberg EP (2004) Promoter specificity in / Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR. Proc Natl Acad Sci USA 101:15833鈥?5839
125. Seet Q, Zhang LH (2011) Anti-activator QslA defines the quorum sensing threshold and response in / Pseudomonas aeruginosa. Mol Microbiol 80:951鈥?65
126. Siehnel R, Traxler B, An DD, Parsek MR, Schaefer AL, Singh PK (2010) A unique regulator controls the activation threshold of quorum-regulated genes in / Pseudomonas aeruginosa. Proc Natl Acad Sci USA 107:7916鈥?921
127. Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Camara M, Williams P, Quax WJ (2006) Quorum quenching by an / N-acyl-homoserine lactone acylase from / Pseudomonas aeruginosa PAO1. Infect Immun 74:1673鈥?682
128. Smith EE, Buckley DG, Wu Z, Saenphimmachak C, Hoffman LR, D鈥橝rgenio DA, Miller SI, Ramsey BW, Speert DP, Moskowitz SM et al (2006) Genetic adaptation by / Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci USA 103:8487鈥?492
129. Solomonson LP (1981) Cyanide as a metabolic inhibitor. In: Vennesland EECB, Knowles CJ, Westley J, Wissing F (eds) Cyanide in biology. Academic Press, London, pp 11鈥?8
130. Stewart GS, Williams P (1992) lux genes and the applications of bacterial bioluminescence. Journal of general microbiology 138:1289鈥?300
131. Strempel N, Neidig A, Nusser M, Geffers R, Vieillard J, Lesouhaitier O, Brenner-Weiss G, Overhage J (2013) Human host defense peptide LL-37 stimulates virulence factor production and adaptive resistance in / Pseudomonas aeruginosa. PLoS One 8:e82240
132. Svitil AL, Cashel M, Zyskind JW (1993) Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in / Escherichia coli. J Biol Chem 268:2307鈥?311
133. Tan TT (2008) 鈥淔uture鈥?threat of gram-negative resistance in Singapore. Ann Acad Med Singap 37:884鈥?90
134. Thompson LS, Webb JS, Rice SA, Kjelleberg S (2003) The alternative sigma factor RpoN regulates the quorum sensing gene rhlI in / Pseudomonas aeruginosa. FEMS Microbiol Lett 220:187鈥?95
135. Toder DS, Gambello MJ, Iglewski BH (1991) / Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR. Mol Microbiol 5:2003鈥?010
136. Van Delden C, Iglewski BH (1998) Cell-to-cell signaling and / Pseudomonas aeruginosa infections. Emerg Infect Dis 4:551鈥?60
137. Van Delden C, Pesci EC, Pearson JP, Iglewski BH (1998) Starvation selection restores elastase and rhamnolipid production in a / Pseudomonas aeruginosa quorum-sensing mutant. Infect Immun 66:4499鈥?502
138. van Delden C, Comte R, Bally AM (2001) Stringent response activates quorum sensing and modulates cell density-dependent gene expression in / Pseudomonas aeruginosa. J Bacteriol 183:5376鈥?384
139. Ventre I, Ledgham F, Prima V, Lazdunski A, Foglino M, Sturgis JN (2003) Dimerization of the quorum sensing regulator RhlR: development of a method using EGFP fluorescence anisotropy. Mol Microbiol 48:187鈥?98
140. von Bodman SB, Willey JM, Diggle SP (2008) Cell鈥揷ell communication in bacteria: united we stand. J Bacteriol 190:4377鈥?391
141. Wade DS, Calfee MW, Rocha ER, Ling EA, Engstrom E, Coleman JP, Pesci EC (2005) Regulation of / Pseudomonas quinolone signal synthesis in / Pseudomonas aeruginosa. J Bacteriol 187:4372鈥?380
142. Westblade LF, Ilag LL, Powell AK, Kolb A, Robinson CV, Busby SJ (2004) Studies of the / Escherichia coli Rsd-sigma70 complex. J Mol Biol 335:685鈥?92
143. Whitchurch CB, Beatson SA, Comolli JC, Jakobsen T, Sargent JL, Bertrand JJ, West J, Klausen M, Waite LL, Kang PJ et al (2005) / Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways. Mol Microbiol 55:1357鈥?378
144. Whitehead NA, Barnard AM, Slater H, Simpson NJ, Salmond GP (2001) Quorum-sensing in Gram-negative bacteria. FEMS Microbiol Rev 25:365鈥?04
145. Whiteley M, Greenberg EP (2001) Promoter specificity elements in / Pseudomonas aeruginosa quorum-sensing-controlled genes. J Bacteriol 183:5529鈥?534
146. Whiteley M, Lee KM, Greenberg EP (1999) Identification of genes controlled by quorum sensing in / Pseudomonas aeruginosa. Proc Natl Acad Sci USA 96:13904鈥?3909
147. Whiteley M, Parsek MR, Greenberg EP (2000) Regulation of quorum sensing by RpoS in / Pseudomonas aeruginosa. J Bacteriol 182:4356鈥?360
148. Williams P, Bainton NJ, Swift S, Chhabra SR, Winson MK, Stewart GS, Salmond GP, Bycroft BW (1992) Small molecule-mediated density-dependent control of gene expression in prokaryotes: bioluminescence and the biosynthesis of carbapenem antibiotics. FEMS Microbiol Lett 100:161鈥?67
149. Winson MK, Camara M, Latifi A, Foglino M, Chhabra SR, Daykin M, Bally M, Chapon V, Salmond GP, Bycroft BW et al (1995) Multiple / N-acyl-l -homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in / Pseudomonas aeruginosa. Proc Natl Acad Sci USA 92:9427鈥?431
150. Winzer K, Falconer C, Garber NC, Diggle SP, Camara M, Williams P (2000) The / Pseudomonas aeruginosa lectins PA-IL and PA-IIL are controlled by quorum sensing and by RpoS. J Bacteriol 182:6401鈥?411
151. Wolz C, Hohloch K, Ocaktan A, Poole K, Evans RW, Rochel N, Albrecht-Gary AM, Abdallah MA, Doring G (1994) Iron release from transferrin by pyoverdin and elastase from / Pseudomonas aeruginosa. Infect Immun 62:4021鈥?027
152. Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX et al (2005) Recognition of host immune activation by / Pseudomonas aeruginosa. Science 309:774鈥?77
153. Xiao G, Deziel E, He J, Lepine F, Lesic B, Castonguay MH, Milot S, Tampakaki AP, Stachel SE, Rahme LG (2006a) MvfR, a key / Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands. Mol Microbiol 62:1689鈥?699
154. Xiao G, He J, Rahme LG (2006b) Mutation analysis of the / Pseudomonas aeruginosa mvfR and / pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry. Microbiology 152:1679鈥?686
155. Yanagihara K, Tomono K, Kaneko Y, Miyazaki Y, Tsukamoto K, Hirakata Y, Mukae H, Kadota J, Murata I, Kohno S (2003) Role of elastase in a mouse model of chronic respiratory / Pseudomonas aeruginosa infection that mimics diffuse panbronchiolitis. Journal of medical microbiology 52:531鈥?35
156. Zaborin A, Romanowski K, Gerdes S, Holbrook C, Lepine F, Long J, Poroyko V, Diggle SP, Wilke A, Righetti K et al (2009) Red death in / Caenorhabditis elegans caused by / Pseudomonas aeruginosa PAO1. Proc Natl Acad Sci USA 106:6327鈥?332
157. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Turner JR et al (2007) Dynorphin activates quorum sensing quinolone signaling in / Pseudomonas aeruginosa. PLoS Pathog 3:e35
158. Zhang L, Murphy PJ, Kerr A, Tate ME (1993) Agrobacterium conjugation and gene regulation by / N-acyl-l -homoserine lactones. Nature 362:446鈥?48 - 刊物主题：Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1674-8018
文摘
Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of the pathogen to form biofilm matrix, which provides bacterial cells a protected environment withstanding various stresses including antibiotics. Quorum sensing (QS), a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection. The QS network of P. aeruginosa is organized in a multi-layered hierarchy consisting of at least four interconnected signaling mechanisms. Evidence is accumulating that the QS regulatory network not only responds to bacterial population changes but also could react to environmental stress cues. This plasticity should be taken into consideration during exploration and development of anti-QS therapeutics.