Structure and properties of silver-doped calcium phosphate nanopowders

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• 作者：RAVINDER PAL SINGH ; UMA BATRA
• 关键词：Sol–gel processes ; calcination ; electron microscopy ; antimicrobial
• 刊名：Bulletin of Materials Science
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：39
• 期：5
• 页码：1285-1294
• 全文大小：6,470 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Materials Science
  Engineering, general
  
• 出版者：Springer India
• ISSN：0973-7669
• 卷排序：39

文摘

Stable and antimicrobial silver-doped calcium phosphate nanopowders were synthesized using sol–gel route by setting the atomic ratio of Ag/(Ag+Ca) at 3% and (Ca+ Ag)/P at 1.67. Prior to synthesis of nanopowders, influence of time of hydrolyzation on pH and density of precursors were comprehensively studied. Hydrolyzation time was found to have profound influence on pH of constituent precursors. Sufficient hydrolysis resulted in early maturation of sol. Scanning electron microscopy (SEM) showed the heterogeneous and agglomerated state of particles with average size of 3.9± 1.9 μm. Energy dispersive X-ray spectroscopy (EDX) presented uniform distribution of O, Ag, Ca and P elements in nanopowder. Fourier transform infrared spectroscopy (FTIR) confirmed the formation of apatitic structure, whereas X-ray diffraction (XRD) revealed the multiphase constitution of nanopowders primarily composed of β-TCP, Ag and other hybrid phases. Crystallite size and lattice parameters of β-TCP and Ag phases were increased with the rise in calcination temperature. Thermogravimetric analysis (TGA) showed three regions of weight change and indicated the high thermal stability of nanopowders. Disk diffusion method was used to test the antimicrobial resistance of nanopowders against Escherichia coli and Staphylococcus aureus bacterial strains. All nanopowders exhibited antimicrobial resistance against both E. coli and S. aureus bacteria.