Evaluation of Cardiovascular Changes in Children with BAVs

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• 作者：S. Hanedan Onan ; A. Baykan ; S. Sezer ; F. Narin ; E. Mavili…
• 关键词：BAV ; Left ventricle ; Aorta ; Atherosclerosis ; Carotid intima–media thickness
• 刊名：Pediatric Cardiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：37
• 期：3
• 页码：472-481
• 全文大小：473 KB
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• 作者单位：S. Hanedan Onan (1) (5)
  A. Baykan (1)
  S. Sezer (1)
  F. Narin (2)
  E. Mavili (3)
  Z. Baykan (4)
  K. Uzum (1)
  N. Narin (1)
  
  1. Department of Pediatric Cardiology, Erciyes University Medical Faculty, Kayseri, Turkey
  5. M.Nesih Ozmen Mah.Emek Sokak, Atabek Sitesi.F Blok.No:20, Merter, Gungoren, Istanbul, Turkey
  2. Department of Biochemistry, Erciyes University Medical Faculty, Kayseri, Turkey
  3. Department of Radiology, Erciyes University Medical Faculty, Kayseri, Turkey
  4. Department of Biostatics, Erciyes University Medical Faculty, Kayseri, Turkey
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  
• 出版者：Springer New York
• ISSN：1432-1971

文摘

The objectives of this study were to investigate left ventricular (LV) function, aortic dilation, and atherosclerosis in children with mildly deteriorated isolated bicuspid aortic valve (BAV) function using echocardiographic studies and biochemical markers of atherosclerosis and to correlate results with normal children. Biochemical analyses indicating cardiovascular risk of atherosclerosis and vascular changes in the aorta in relation to BAV were performed in 41 children aged 5–15 years old with isolated BAV and in 25 children with tricuspid aortic valves. Evaluations of aortic valve structures and functions; examinations of the LV M-mode and ascending aorta Doppler; and measurements of the LV Tei index (MPI), propagation velocity, ascending aorta at four levels, and carotid intima–media thickness (CIMT) were performed. There were no statistically significant differences in CIMTs, plasma matrix metalloproteinase-9, tissue metalloproteinase inhibitor-1 levels, or other biochemical parameters indicating cardiovascular risk or atherosclerosis between study and control groups. Deterioration of LV function, which could not be seen with M-mode echocardiography, was evident by MPI. MPI values in the study versus control groups were 0.46 ± 0.080 versus 0.40 ± 0.086 (p < 0.05). Diameters of the aorta in the study and control groups were 19.7 ± 4.7 and 17.2 ± 2.8 mm (p < 0.05) at the sinotubular junction level and 20.6 (14.4–40.5) and 18.3 (12.4–24) mm at the ascending aorta level (p < 0.05). Increased aortic valve insufficiency was related to increased aortic diameter. No sign of atherosclerosis was detected in children with BAV. Deterioration of LV function was seen using MPI, and aortic dilation was related to the severity of aortic valve insufficiency.