A Paradox: α-Klotho Levels and Smoking Intensity

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• 作者：Zoraida Verde ; Jose M. Rodríguez González-Moro ; Luis M. Chicharro…
• 关键词：Healthy smokers ; α ; Klotho ; Aging ; Packs year smoked ; Cigarettes per day
• 刊名：Lung
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：195
• 期：1
• 页码：53-57
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pneumology/Respiratory System;
• 出版者：Springer US
• ISSN：1432-1750
• 卷排序：195

文摘

Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population.