Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients

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• 作者：Rasmus Lykke Marvig ; Daniela Dolce ; Lea M. Sommer ; Bent Petersen…
• 关键词：Bacterial pathogens ; Genetic adaptation ; Evolution ; Cystic fibrosis
• 刊名：BMC Microbiology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：733 KB
• 刊物主题：Microbiology; Biological Microscopy; Fungus Genetics; Parasitology; Virology; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-2180

文摘

Background Chronic infection with Pseudomonas aeruginosa is a major cause of morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of P. aeruginosa within-host genomic evolution, transmission, and population genomics may provide a basis for improving intervention strategies. Here, we report the first genomic analysis of P. aeruginosa isolates sampled from Italian CF patients.