SOX2 Inhibition Promotes Promoter Demethylation of CDX2 to Facilitate Gastric Intestinal Metaplasia

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• 作者：Haijing Niu ; Yuchen Jia ; Tao Li ; Bingzhong Su
• 关键词：Gastric mucosa ; Intestinal metaplasia ; SOX2 ; CDX2 ; DNA methylation
• 刊名：Digestive Diseases and Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：62
• 期：1
• 页码：124-132
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general;
• 出版者：Springer US
• ISSN：1573-2568
• 卷排序：62

文摘

BackgroundGastric intestinal metaplasia (IM) is regarded as a premalignant lesion, conferring risks for gastric cancer development. An intestinal transcription factor, CDX2, plays a vital role in establishing and maintaining IM. SOX2, an HMG-box transcription factor, is expressed in normal gastric mucosa and downregulated in IM. Therefore, it is important to elucidate the mutual interaction of SOX2 and CDX2 in gastric IM.