MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis

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• 作者：Celia S. L. Mak ; Mingo M. H. Yung ; Lynn M. N. Hui ; Leanne L. Leung…
• 关键词：miR ; 141 ; Anoikis resistance ; Ovarian cancer ; KLF12 ; Sp1 ; survivin
• 刊名：Molecular Cancer
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：4765KB
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1476-4598
• 卷排序：16

文摘

BackgroundCancer metastasis is determined by the formation of the metastatic niche and the ability of cancer cells to adapt to microenvironmental stresses. Anoikis resistance is a fundamental feature of metastatic cancer cell survival during metastatic cancer progression. However, the mechanisms underlying anoikis resistance in ovarian cancer are still unclear.