Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
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- 作者：Kurt Hanevik ; Einar Kristoffersen ; Kristine Mørch ; Kristin Paulsen Rye…
- 关键词：Giardia ; T cell ; Chronic fatigue syndrome ; Antigen ; specific ; Immune response ; sCD40L
- 刊名：BMC Immunology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：848KB
- 刊物主题：Immunology; Allergology; Vaccine; Cytokines and Growth Factors;
- 出版者：BioMed Central
- ISSN：1471-2172
- 卷排序：18
文摘
BackgroundThe role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. The aim of this study was to evaluate specific anti-Giardia cellular immunity in cases that developed CFS after Giardia infection compared to cases that recovered well. Patients reporting chronic fatigue in a questionnaire study three years after a Giardia outbreak were clinically evaluated five years after the outbreak and grouped according to Fukuda criteria for CFS and idiopathic chronic fatigue. Giardia specific immune responses were evaluated in 39 of these patients by proliferation assay, T cell activation and cytokine release analysis. 20 Giardia exposed non-fatigued individuals and 10 healthy unexposed individuals were recruited as controls.