Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans

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• 作者：Bryan C. Bergman ; Joseph T. Brozinick ; Allison Strauss ; Samantha Bacon…
• 关键词：Athlete’s paradox ; Insulin sensitivity ; Lipid composition
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：59
• 期：4
• 页码：785-798
• 全文大小：952 KB
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• 作者单位：Bryan C. Bergman (1)
  Joseph T. Brozinick (2)
  Allison Strauss (1)
  Samantha Bacon (1)
  Anna Kerege (1)
  Hai Hoang Bui (2)
  Phil Sanders (2)
  Parker Siddall (2)
  Tao Wei (2)
  Melissa K. Thomas (2)
  Ming Shang Kuo (2)
  Leigh Perreault (1)
  
  1. Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, PO Box 6511, MS 8106, Aurora, CO, 80045, USA
  2. Eli Lilly and Company, Indianapolis, IN, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypotheses Ceramides and other sphingolipids comprise a family of lipid molecules that accumulate in skeletal muscle and promote insulin resistance. Chronic endurance exercise training decreases muscle ceramides and other sphingolipids, but less is known about the effects of a single bout of exercise.