Importance of intestinal microenvironment in development of arthritis. A systematic review

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• 作者：Anna Bazsó ; Péter Szodoray ; Gábor Süt? ; Yehuda Shoenfeld…
• 关键词：Intestinal microenvironment ; Spondylarthropathy ; Colonisation ; Gut
• 刊名：Immunologic Research
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：61
• 期：1-2
• 页码：172-176
• 全文大小：210 KB
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• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

A strong connection between spondylarthropathies and inflammatory bowel diseases (IBD) is well established. About 10-5?% of IBD are associated with different forms of spondylarthritis. Arthritis can be manifested as axial, peripheral form or both. The primary functions of the gastrointestinal tract are digestion and absorption of nutrients, electrocytes and maintenance of water homoeostasis. The anatomic and functional lesions could lead to the development of IBD based on molecular mimicry and bystander effects. The mechanism of the macromolecules is uptaken may affect intestinal and extraintestinal manifestation in genetically susceptible individuals by gut-associated lymphoid tissue, the interplay between innate and adaptive immunity and the neuroendocrine network.