参考文献:1.Zhao Z, Chen CC, Rillahan CD et al (2015) Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet 47:539鈥?43CrossRef PubMed 2.Zebisch A, Sill H (2008) Are mouthwashes a reliable source of constitutional DNA in patients with leukemia? Leuk Res 32:1164鈥?165CrossRef PubMed 3.Zebisch A, Staber PB, Delavar A et al (2006) Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia. Cancer Res 66:3401鈥?408CrossRef PubMed 4.Zebisch A, Haller M, Hiden K et al (2009) Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations. Leukemia 23:1049鈥?053CrossRef PubMed 5.Zebisch A, Wolfler A, Fried I et al (2012) Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia. Leukemia 26:1842鈥?849CrossRef PubMed 6.Wilke K, Duman B, Horst J (2000) Diagnosis of haploidy and triploidy based on measurement of gene copy number by real-time PCR. Hum Mutat 16:431鈥?36CrossRef PubMed 7.Cancer Genome Atlas Research Network (2013) Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 368:2059鈥?074CrossRef
作者单位:Olivia Geiger (1) Stefan Hatzl (1) Karl Kashofer (2) Gerald Hoefler (2) Albert W枚lfler (1) Heinz Sill (1) Armin Zebisch (1)
1. Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, 8036, Graz, Austria 2. Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria