Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation
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- 作者：Kazuo Furukawa ; Ichiro Fuse ; Yuriko Iwakura…
- 关键词：AGE ; BDNF ; Platelets ; Release ; Ca2+ ; Src family kinases ; Syk
- 刊名：Cardiovascular Diabetology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1093KB
- 刊物主题：Diabetes; Angiology; Cardiology;
- 出版者：BioMed Central
- ISSN：1475-2840
- 卷排序：16
文摘
BackgroundBrain-derived neurotrophic factor (BDNF) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. There is argument regarding the levels of serum BDNF in patients with diabetes mellitus (DM). Because BDNF in peripheral blood is rich in platelets, this may represent dysregulation of BDNF release from platelets. Here we focused on advanced glycation end products (AGEs), which are elevated in patients with DM and have adverse effects on cardiovascular functions. The aim of this study is to elucidate the role of AGEs in the regulation of BDNF release from human platelets.