Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms
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- 作者：David Kadosh
- 关键词：C. albicans ; Morphogenesis ; Virulence ; Translational control ; mRNA stability ; Alternative transcript localization ; Antifungal strategies
- 刊名：Cellular and Molecular Life Sciences (CMLS)
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：73
- 期：22
- 页码：4265-4278
- 全文大小：1,023 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Biomedicine
Life Sciences
Biochemistry - 出版者：Birkh盲user Basel
- ISSN：1420-9071
- 卷排序：73
文摘
Candida albicans is a major human fungal pathogen responsible for both systemic and mucosal infections in a wide variety of immunocompromised individuals. Because the ability of C. albicans to undergo a reversible morphological transition from yeast to filaments is important for virulence, significant research efforts have focused on mechanisms that control this transition. While transcriptional and post-translational mechanisms have been well-studied, considerably less is known about the role of post-transcriptional mechanisms. However, in recent years several discoveries have begun to shed light on this important, but understudied, area. Here, I will review a variety of post-transcriptional mechanisms that have recently been shown to control C. albicans morphology, virulence and/or virulence-related processes, including those involving alternative transcript localization, mRNA stability and translation. I will also discuss the role that these mechanisms play in other pathogens as well as the potential they may hold to serve as targets for new antifungal strategies. Ultimately, gaining a better understanding of C. albicans post-transcriptional mechanisms will significantly improve our knowledge of how morphogenesis and virulence are controlled in fungal pathogens and open new avenues for the development of novel and more effective antifungals.