Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis
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- 作者：Sanae Haga ; Yimin ; Michitaka Ozaki
- 关键词：FXR ; p62/SQSTM1 ; Nrf2 ; SHP ; Oxidative stress ; Liver injury ; Steatosis
- 刊名：BMC Gastroenterology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：3127KB
- 刊物主题：Gastroenterology; Internal Medicine; Hepatology;
- 出版者：BioMed Central
- ISSN：1471-230X
- 卷排序：17
文摘
BackgroundLiver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failure, especially with some underlying pathological conditions such as steatosis. Therefore, protection from the injury of hepatocytes and liver is a serious concern in various clinical settings.