Biochemical mechanism underlying hypertriglyceridemia and hepatic steatosis/hepatomegaly induced by acute schisandrin B treatment in mice
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- 作者：Yi Zhang ; Jing Zhao ; Shu-Feng Zhou ; Zhi-Ling Yu…
- 关键词：Schisandrin B ; Hypertriglyceridemia ; Lipolysis ; Chylomicron ; Hepatomegaly ; Hepatic steatosis
- 刊名：Lipids in Health and Disease
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：3685KB
- 刊物主题：Lipidology; Medical Biochemistry; Clinical Nutrition;
- 出版者：BioMed Central
- ISSN：1476-511X
- 卷排序：16
文摘
BackgroundIt has been demonstrated that acute oral administration of schisandrin B (Sch B), an active dibenzocyclooctadiene isolated from Schisandrae Fructus (a commonly used traditional Chinese herb), increased serum and hepatic triglyceride (TG) levels and hepatic mass in mice. The present study aimed to investigate the biochemical mechanism underlying the Sch B-induced hypertriglyceridemia, hepatic steatosis and hepatomegaly.