The effects of methylphenidate and propranolol on the interplay between induced-anxiety and working memory

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• 作者：Monique Ernst ; Tiffany Lago ; Andrew Davis ; Christian Grillon
• 关键词：Fear ; potentiated startle ; Stimulant ; Cognition ; Limited resources theory ; Dopamine ; Catecholamine
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：233
• 期：19-20
• 页码：3565-3574
• 全文大小：946 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072
• 卷排序：233

文摘

RationaleResearch documents a reciprocal impact of anxiety on working memory (WM), although its strength and direction depend on factors like task difficulty. A better understanding of these factors may generate insights into cognitive mechanisms of action involved in anxiety, culminating into treatment implications. By blocking the physiological effects of anxiety, propranolol might also block anxiety interference on WM. Conversely, by improving task-directed attention, methylphenidate might reduce anxiety, or, alternatively, by improving cognitive efficiency and free up processing resources to compute anxiety.