Pre-operative opioid analgesia reduces clinical success of laparoscopic gastric electrical stimulation placement in patients with gastroparesis

详细信息    查看全文

• 作者：Mena Boules ; Hideharu Shimizu ; Andrea Zelisko ; Kevin El-Hayek…
• 关键词：Gastric pacemaker ; Gastric electrical stimulator (GES) ; Opioid analgesia ; Endoscopy
• 刊名：Surgical Endoscopy
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：29
• 期：4
• 页码：805-809
• 全文大小：387 KB
• 参考文献：1. Camilleri, M, Parkman, HP, Shafi, MA, Abell, TL, Gerson, L (2013) Clinical guideline: management of gastroparesis. Am J Gastroenterol 108: pp. 18-37 CrossRef
  2. Stanghellini, V, Tosetti, C, Paternico, A, Barbara, G, Morselli-Labate, AM, Monetti, N, Marengo, M, Corinaldesi, R (1996) Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 110: pp. 1036-1042 CrossRef
  3. Camilleri, M, Bharucha, AE, Farrugia, G (2011) Epidemiology, mechanisms, and management of diabetic gastroparesis. Clin Gastroenterol Hepatol 9: pp. 5-12 CrossRef
  4. Nozu, T, Kudaira, M (2009) Altered rectal sensory response induced by balloon distention in patients with functional abdominal pain syndrome. Biopsychosoc Med 3: pp. 13 CrossRef
  5. Mercadante, S, Villari, P, Ferrera, P (2003) Burst ketamine to reverse opioid tolerance in cancer pain. J Pain Symptom Manag 25: pp. 302-305 CrossRef
  6. Mercadante, S, Arcuri, E (2005) Hyperalgesia and opioid switching. Am J Hosp Palliat Care 22: pp. 291-294 CrossRef
  7. Mao, J, Sung, B, Ji, R–R, Lim, G (2002) Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci 22: pp. 7650-7661
  8. Pud, D, Cohen, D, Lawental, E, Eisenberg, E (2006) Opioids and abnormal pain perception: new evidence from a study of chronic opioid addicts and healthy subjects. Drug Alcohol Depend 82: pp. 218-223 CrossRef
  9. Crain, SM, Shen, KF (2000) Antagonists of excitatory opioid receptor functions enhance morphine’s analgesic potency and attenuate opioid tolerance/dependence liability. Pain 84: pp. 121-131 CrossRef
  10. Grunkemeier, DMS, Cassara, JE, Dalton, CB, Drossman, DA (2007) The narcotic bowel syndrome: clinical features, pathophysiology, and management. Clin Gastroenterol Hepatol 5: pp. 1126-1139 CrossRef
  11. Farmer, AD, Ferdinand, E, Aziz, Q (2013) Opioids and the gastrointestinal tract—a case of narcotic bowel syndrome and literature review. J Neurogastroenterol Motil 19: pp. 94-98 CrossRef
  12. Watkins, LR, Hutchinson, MR, Johnston, IN, Maier, SF (2005) Glia: novel counter-regulators of opioid analgesia. Trends Neurosci 28: pp. 661-669 CrossRef
  13. Timratana, P, El-Hayek, K, Shimizu, H, Kroh, M, Chand, B (2013) Laparoscopic gastric electrical stimulation for medically refractory diabetic and idiopathic gastroparesis. J Gastrointest Surg 17: pp. 461-470 CrossRef
  14. Brock, C, Olesen, SS, Olesen, AE, Fr?kjaer, JB, Andresen, T, Drewes, AM (2012) Opioid-induced bowel dysfunction: pathophysiology and management. Drugs 72: pp. 1847-1865 CrossRef
  15. Leppert, W (2013) New treatment possibilities for opioid-induced bowel dysfunction. Pain 154: pp. 1491-1492 CrossRef
  16. Benyamin, R, Trescot, AM, Datta, S, Buenaventura, R, Adlaka, R, Sehgal, N, Glaser, SE, Vallejo, R (2008) Opioid complications and side effects. Pain Phys 11: pp. S105-S120
  17. Ketwaroo, GA, Cheng, V, Lembo, A (2013) Opioid-induced bowel dysfunction. Curr Gastroenterol Rep 15: pp. 344 CrossRef
  18. Camilleri, M (2011) Opioid-induced constipation: cha
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Gynecology
  Gastroenterology
  Hepatology
  Proctology
  Abdominal Surgery
  
• 出版者：Springer New York
• ISSN：1432-2218

文摘

Introduction Gastroparesis is a common chronic and costly disorder for which medical therapy is often unsuccessful. Gastric electrical stimulation (GES) has been used to treat refractory cases, however, response is variable and difficult to predict. This study aims to assess whether pre-operative opioid analgesics (OA) use affects clinical success of GES. Methods Records of 128 patients who underwent laparoscopic GES placement from March 2001 to September 2012 were analyzed retrospectively. Data collected included demographics, surgical outcomes, and clinical parameters. Pre- and post-operative opioid analgesic dosing (No?=?0 morphine equivalents (ME)/day, Low?=?0-0?ME/day, Mid?=?41-0?ME/day, High >80?ME/day), as well as clinical symptom assessment was collected for up to 3?years post-operatively. Clinical success was defined as (1) OA reduction of >50?%, (2) maintenance of weight, or (3) symptom improvement. Descriptive statistics were computed for all factors. A p? Results Fifty-three patients were on OA pre-operatively compared to 69 patients who were not. Patients not on OA pre-operatively were less likely than those on OA pre-op group to be on OA post-operatively (p?=?0.005); however, there were no differences in weight or symptom improvement. Sub-group analysis of the 53 patients on OA demonstrated significant improvement in clinical symptoms in the low-morphine cohort compared to the mid-morphine cohort (p?=?0.02), and OA dosing post-operatively in the low-morphine cohort diminished significantly compared to mid- and high-morphine cohort (p?=?0.032). There was no significant difference in weight. Conclusion OA dosing pre-operatively significantly affects clinical success of GES placement. Criteria for offering GES implantation may need to take OA dosing into consideration.