Link between aortic valve sclerosis and myocardial no-reflow in ST-segment elevation myocardial infarction

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• 作者：L. Korkmaz MD ; H. Erkan ; M.T. Ağaç ; E. Pelit ; H. Bektas ; Z. Acar ; I. Gurbak…
• 关键词：Aortic valve sclerosis ; Myocardial infarction ; No ; reflow phenomenon ; ST ; segment elevation myocardial infarction ; Prognosis ; Aortenklappensklerose ; Herzinfarkt ; Fehlende Perfusion ; ST ; Strecken ; Hebungs ; Infarkt ; Prognose
• 刊名：Herz
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：40
• 期：3
• 页码：502-506
• 全文大小：432 KB
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• 作者单位：L. Korkmaz MD (1)
  H. Erkan (1)
  M.T. A?a? (1)
  E. Pelit (1)
  H. Bektas (1)
  Z. Acar (1)
  I. Gurbak (1)
  F. Kara (1)
  ?. ?elik (1)
  
  1. Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  
• 出版者：Urban & Vogel
• ISSN：1615-6692

文摘

Objective The“no-reflow‰henomenon is associated with a worse prognosis at follow-up for patients with acute ST-segment elevation myocardial infarction (STEMI). Predicting and preventing no-reflow is therefore a crucial step in improving the prognosis of STEMI patients. The purpose of this study was to investigate the association between aortic valve sclerosis (AVS) and myocardial no-reflow in patients with STEMI. Patients and methods Patients with a first-time diagnosis of STEMI were enrolled consecutively. No-reflow was defined as a final TIMI 3 flow with a myocardial blush of grade < temporary epicardial coronary no-reflow, and distal coronary occlusion. AVS was defined by echocardiography as thickening and calcification of the normal trileaflet aortic valve without obstruction to the left ventricular outflow. Results No-reflow developed in 41patients. In univariate analysis, age, male gender, smoking, culprit lesion Syntax score (SX score), and hypertension were significantly associated with no-reflow. Multivariate binary logistic regression analyses demonstrated age [95confidence interval (CI), 1.024096; p=0.001), AVS (95CI, 1.002100; p=0.039], culprit lesion SX score (95CI, 1.08021 p=0.008), and symptom-to-balloon time (95CI, 1.020097; p=0.002) as independent determinants of myocardial no-reflow. Conclusion AVS was significantly and independently associated with myocardial no-reflow in STEMI patients.