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Long-term outcomes (>5-year follow-up) with porcine acellular dermal matrix (Permacol鈩? in incisional hernias at risk for infection
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  • 作者:M. M. Abdelfatah (1)
    N. Rostambeigi (1)
    E. Podgaetz (1)
    M. G. Sarr (1)

    1. Division of Gastroenterologic and General Surgery
    ; Department of Surgery ; Mayo Clinic ; 200 1st St SW ; Rochester ; MN ; 55905 ; USA
  • 关键词:Abdominal wall reconstruction ; Bioprosthesis ; Porcine acellular dermal matrix ; Recurrent hernia ; Mesh infection
  • 刊名:Hernia
  • 出版年:2015
  • 出版时间:February 2015
  • 年:2015
  • 卷:19
  • 期:1
  • 页码:135-140
  • 全文大小:220 KB
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    7. Loganathan A, Ainslie WG, Wedgwood KR (2010) Initial evaluation of Permacol bioprosthesis for the repair of complex incisional and parastomal hernias. Surgeon 8:202鈥?05 CrossRef
    8. Shaikh FM, Giri SK, Durrani S, Waldron D, Grace PA (2007) Experience with porcine acellular dermal collagen implant in one-stage tension-free reconstruction of acute and chronic abdominal wall defects. World J Surg 31:1966鈥?972 (discussion 1973鈥?964, 1975) CrossRef
    9. Hsu PW, Salgado CJ, Kent K, Finnegan M, Pello M, Simons R, Atabek U, Kann B (2009) Evaluation of porcine dermal collagen (Permacol) used in abdominal wall reconstruction. J Plast Reconstr Aesthet Surg 62:1484鈥?489 CrossRef
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  • 刊物类别:Medicine
  • 刊物主题:Medicine & Public Health
    Abdominal Surgery
  • 出版者:Springer Paris
  • ISSN:1248-9204
文摘
Purpose We reviewed retrospectively all patients undergoing abdominal wall reconstruction using porcine acellular dermal matrix (PADM) from 2004 to 2008 with follow-up assessment in 2012. Technique, short-term (infection, seroma, wound dehiscence), and long-term (mesh infection, recurrence) complications, and hernia recurrences were evaluated by physician examination 鈮?聽years postoperatively. Results 56 patients at high risk for infection had elective operation; nine had non-elective operation for complications of prior incisional hernia/hernia repair. Operations were clean, clean-contaminated, contaminated, or grossly infected in 49, 32, 12, and 6聽%, respectively. Techniques of repair included 10 onlay (six reinforced primary closures, four bridging patches), 47 sublay (20 reinforced primary closures, 27 bridging patches), six inlay, and two sandwich (sublay and onlay). Early complications (鈮?0聽days postoperatively) occurred in 19 of the 65 patients (29聽%), including two prosthetic dehiscences from fascial attachment, 13 wound infections, and 4 seromas. After a mean follow-up of 鈮?聽years in 59 of 65 patients, physician-reported incidences of infection requiring removal of mesh or hernia recurrence were 25 and 66聽%, respectively. Hernia recurrence occurred in 12 of 26 (46聽%) patients with a reinforced repair and 27 of 33 (82聽%) with patched repairs. Mesh infection occurred in 7 of 24 patients with sublay patch and in 4 of 19 sublay reinforcement. The greatest recurrence rate was in contaminated (71聽%) and grossly infected wounds (100聽%), while recurrence rate was 63聽% in clean and 63聽% in clean-contaminated wounds. Conclusions At 鈮?聽years of follow-up, use of PADM as a bioprosthesis in ventral hernia in high-risk patients is unreliable as a definitive repair in the majority of patients, but may provide satisfactory outcomes in some patients.

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