Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma

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• 作者：Hidenari Hirata MD ; Keishi Sugimachi MD ; PhD…
• 刊名：Annals of Surgical Oncology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：22
• 期：3-supp
• 页码：1402-1409
• 全文大小：778 KB
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• 作者单位：Hidenari Hirata MD (1) (2)
  Keishi Sugimachi MD, PhD (1)
  Yusuke Takahashi MD, PhD (1) (3)
  Masami Ueda MD (1)
  Shotaro Sakimura MD (1)
  Ryutaro Uchi MD (1)
  Junji Kurashige MD, PhD (1)
  Yuki Takano MD (1)
  Sho Nanbara MD (1)
  Hisateru Komatsu MD (1)
  Tomoko Saito MD (1)
  Yoshiaki Shinden MD (1)
  Tomohiro Iguchi MD, PhD (1)
  Hidetoshi Eguchi MD, PhD (1)
  Kazushige Atsumi MD, PhD (2)
  Katsumi Sakamoto MD, PhD (2)
  Toshiro Doi MD, PhD (4)
  Masakazu Hirakawa MD, PhD (2)
  Hiroshi Honda MD, PhD (5)
  Koshi Mimori MD, PhD (1)
  
  1. Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan
  2. Department of Radiology, Kyushu University Beppu Hospital, Beppu, Japan
  3. Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan
  4. Department of Orthopedic Surgery, Kyushu University Beppu Hospital, Beppu, Japan
  5. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  
• 刊物主题：Surgical Oncology; Oncology; Surgery;
• 出版者：Springer US
• ISSN：1534-4681

文摘

Background Downregulation of paired related homeobox 1 (PRRX1) is associated with the acquisition of cancer stem cell (CSC)-like properties and poor prognosis in cancers. The purpose of this study is to clarify the role of PRRX1 expression in predicting prognosis and mediating CSC-like properties in hepatocellular carcinoma (HCC).