Intravenous dezocine pretreatment reduces the incidence and intensity of myoclonus induced by etomidate
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- 作者：Zhifeng Lu (1)
Jie Fang (2)
Jianpo Zhu (2)
Bing Liang (2)
Fangkun Li (2)
Suli Jiang (2)
Ali Li (2)
Zhifang Cheng (2)
Tieli Dong (1) - 关键词：Etomidate ; Dezocine ; Myoclonus
- 刊名：Journal of Anesthesia
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：28
- 期：6
- 页码：944-947
- 全文大小：165 KB
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Ali Li (2)
Zhifang Cheng (2)
Tieli Dong (1)
1. Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University, No. 2 Jingba Road, Zhengzhou, Henan, China
2. Department of Anesthesia, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China - ISSN：1438-8359
文摘
To evaluate the suppressive effect of intravenous dezocine on the incidence and severity of myoclonic movements induced by etomidate, a total of 80 patients, American Society of Anesthesiologists physical status I–II, were randomized into two equally sized groups (n?=?40). These two groups were assigned to give either intravenous dezocine 0.1?mg/kg or a matching placebo (equal volume of 0.9?% saline) 30?s before administration of etomidate. For anesthesia induction, 0.3?mg/kg etomidate was injected over a period of 1?min. One minute after etomidate administration, the severity of myoclonus was assessed. Pretreatment with dezocine significantly reduced both the incidence and intensity of myoclonus. These results demonstrate that intravenous dezocine 0.1?mg/kg 30?s prior to induction was effective in suppressing myoclonic movements in our patients.